Results 131 to 140 of about 2,494,853 (253)

Bioinformatics Applications to Reveal Molecular Mechanisms of Gene Expression Regulation in Model Organisms. [PDF]

Int J Mol Sci, 2021
Orlov YL, Tatarinova TV, Anashkina AA.
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer. [PDF]

Commun Biol
Zhang N, Wang X, Li Y, Lu Y, Sheng C, Sun Y, Ma N, Jiao Y.   +7 more
europepmc   +1 more source

RBM22, a Key Player of Pre-mRNA Splicing and Gene Expression Regulation, Is Altered in Cancer. [PDF]

Cancers (Basel), 2022
Soubise B, Jiang Y, Douet-Guilbert N, Troadec MB.   +3 more
europepmc   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Dynamic Chromatin Accessibility and Gene Expression Regulation During Maize Leaf Development. [PDF]

Genes (Basel)
Wang Y, Wang S, Wu Y, Cheng J, Wang H.
europepmc   +1 more source

Uncovering Divergence in Gene Expression Regulation in the Adaptation of Yeast to Nitrogen Scarcity. [PDF]

mSystems, 2021
Villarroel CA, Bastías M, Canessa P, Cubillos FA.   +3 more
europepmc   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Integrated Genomic Analysis Reveals the Impact of Avermectin on Chromatin Structure and Gene Expression Regulation in <i>Bombyx mori</i>. [PDF]

Insects
Guo Y, Zhang T, Lu W, Liu D, Lao J, Zhang N, Sun H, Jia L, Ma S.   +8 more
europepmc   +1 more source

Prediction of gene expression regulation by human microRNAs in Plasmodium falciparum. [PDF]

Genes Environ, 2021
Grinev A, Fokina N, Bogomolov D, Berechikidze I, Lazareva Y.   +4 more
europepmc   +1 more source