Results 161 to 170 of about 8,100,350 (339)

Chromatin context shapes SPT5 regulation of promoter-proximal Pol II, fine-tuning gene expression changes during Drosophila embryogenesis

Alessandro Dulja, Marvin Mayer, Niklas Engel, Arkadiy K. Golov, Katharina Bender, Mattia Forneris, Yacine Kherdjemil, Songjie Feng, Rebecca R. Viales, Eileen E. M. Furlong   +9 more
openalex   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Transcription Factors in Plant Gene Expression Regulation. [PDF]

Int J Mol Sci
Szymczyk P.
europepmc   +1 more source

Replication mechanisms of circular ssDNA plant viruses and their potential implication in viral gene expression regulation. [PDF]

mBio, 2023
Bonnamy M, Blanc S, Michalakis Y.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Systems Biology Analysis of Spaceflight-Induced MicroRNA Regulation and Cross-Tissue Gene Expression across the Liver-Brain Axis

Pratheek Mukkavilli, Michelle Medeiros, Rosa Prahl, Xavier‐Lewis Palmer   +3 more
openalex   +2 more sources

Specific Methyl-CpG Configurations Define Cell Identity through Gene Expression Regulation. [PDF]

Int J Mol Sci, 2023
Improda T, Morgera V, Vitale M, Chiariotti L, Passaro F, Feola A, Porcellini A, Cuomo M, Pezone A.   +8 more
europepmc   +1 more source

THE EFFECT OF MATERNAL OBESITY ON THE REGULATION OF GENE EXPRESSION AND CELL FATE DURING EMBRYONIC CORTICAL NEUROGENESIS

Thilina Alawathugoda
openalex   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

m¹A RNA Modification in Gene Expression Regulation. [PDF]

Genes (Basel), 2022
Jin H, Huo C, Zhou T, Xie S.
europepmc   +1 more source