Results 181 to 190 of about 1,893,780 (318)

A Novel mechanism for depot-specific leptin gene expression regulation and its persistence after weight loss. [PDF]

iScience
Taege N, Britsemmer JH, Israel A, Krause C, Junge S, Feuchtinger A, Ussar S, Pfluger PT, Gemoll T, Schriever SC, Kirchner H.   +10 more
europepmc   +1 more source

Development of chloroplast transformation and gene expression regulation technology in land plants. [PDF]

Front Plant Sci, 2022
An Y, Wang Y, Wang X, Xiao J.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Nutritional Gene Expression Regulation Potential of a Lysolecithin-Based Product. [PDF]

Curr Issues Mol Biol
Van Hoeck V, Spaepen R, Forier B.
europepmc   +1 more source

Predictive modeling of gene expression regulation. [PDF]

BMC Bioinformatics, 2021
Regondi C, Fratelli M, Damia G, Guffanti F, Ganzinelli M, Matteucci M, Masseroli M.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Adaptation to Nighttime Light via Gene Expression Regulation in <i>Drosophila suzukii</i>. [PDF]

Ecol Evol
Takenaka N, Takahashi Y.
europepmc   +1 more source

Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor. [PDF]

J Biol Chem, 2023
Burghi V, Paradis JS, Officer A, Adame-Garcia SR, Wu X, Matthees ESF, Barsi-Rhyne B, Ramms DJ, Clubb L, Acosta M, Tamayo P, Bouvier M, Inoue A, von Zastrow M, Hoffmann C, Gutkind JS.   +15 more
europepmc   +1 more source

Feedback regulation of Ran gene expression by Ran protein

, 2011
National Natural Science Foundation of China [30830084]; Hi-Tech Research and Development Program of China (863 program of China) [2010AA09Z403]; Ministry of Agriculture, China [201103034]; Chinese Universities Scientific FundRan, an abundant GTPase that
Wang, Jiajia, Zhang, Xiaobo, Zhao, Zhe, 赵哲   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source