Results 281 to 290 of about 8,100,350 (339)
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Regulated Gene Expression in Gene Therapy
Annals of the New York Academy of Sciences, 2001Abstract: The original model of gene therapy, that of efficient delivery, durable transfer, and stable expression of transgenes to correct a gene defect underlying an inherited disease, is limited in light of improved understanding of the processes involved.
P W, Zoltick, J M, Wilson
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New England Journal of Medicine, 1994
Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
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Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
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Dimerizer-regulated gene expression
Current Opinion in Biotechnology, 2002Control of gene expression using small molecules is a powerful research tool and has clinical utility in the context of regulated gene therapy. Use of chemical inducers of dimerization, or dimerizers, for this purpose has several advantages, including tight regulation, modularity to facilitate iterative improvements, and assembly from human proteins to
Roy, Pollock, Tim, Clackson
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British Medical Bulletin, 1991
A fundamental tenet of biology is that the phenotype of an organism is ultimately determined by its complement of genes. In multicellular organisms, it is the regulated pattern of expression of genes which determines the proliferation and differentiation of individual cell lineages and hence establishes the adult phenotype.
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A fundamental tenet of biology is that the phenotype of an organism is ultimately determined by its complement of genes. In multicellular organisms, it is the regulated pattern of expression of genes which determines the proliferation and differentiation of individual cell lineages and hence establishes the adult phenotype.
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Regulation of Cytokine Gene Expression
Annual Review of Immunology, 1988Following the isolation and characterization of many cytokine genes, we began to understand the mechanisms regulating cytokine gene expression. Needless to say, understanding the mechanisms by which induction of gene expression occurs in a transient, cell type-specific manner in response to extracellular inducers is a central issue in eukaryotic ...
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Regulation of gene expression by hypoxia
Biochemical Journal, 2008Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF regulation have greatly enhanced our knowledge of the molecular aspects of the hypoxic response.
Kenneth, Niall Steven, Rocha, Sonia
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Nutritional regulation of gene expression
Theory in Biosciences, 2001The human genome has now been mapped with a complete sequence to follow shortly. The race is on to apply the vast amount of information contained in the billions of base-pairs. Concurrently, there is an increased demand from the public for perceived natural products.
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Ploidy Regulation of Gene Expression
Science, 1999Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiae strains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type.
T, Galitski +4 more
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Regulation Of Neuropeptide Gene Expression
Annual Review of Neuroscience, 1990Understanding of the mechanisms of neuropeptide gene regulation has increased dramatically in the past 5 years. In large part, this increased understanding has resulted from advances in the technology of introducing reporter genes into intact cells in culture.
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Nongenomic regulation of gene expression
Current Opinion in Pediatrics, 2016Purpose of review The purpose of this review is to highlight the recent advances in epigenetic regulation and chromatin biology for a better understanding of gene regulation related to human disease. Recent findings Alterations to chromatin influence genomic function, including gene
Isabel, Iglesias-Platas, David, Monk
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