Results 301 to 310 of about 1,661,421 (342)
Some of the next articles are maybe not open access.
Regulation of chondrocyte gene expression
Frontiers in Bioscience, 1999Extracellular influences known to affect the regulation of chondrocyte biosynthetic and catabolic activity have been shown to include soluble factors, extracellular matrix and mechanical stress. A balance of these numerous extracellular influences is required for normal function of articular cartilage. It is likely that OA is the result of an imbalance
openaire +3 more sources
Regulation of gene expression by hypoxia
Biochemical Journal, 2008Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF regulation have greatly enhanced our knowledge of the molecular aspects of the hypoxic response.
Kenneth, Niall Steven, Rocha, Sonia
openaire +4 more sources
Regulating gene expression in gene therapy
Trends in Biotechnology, 1993Ensuring that expression of introduced genes is both safe and effective necessitates directing expression to the appropriate tissue, at levels which produce a therapeutic effect. Extensive research is under way to elucidate the mechanisms and genetic elements involved in regulating expression. With the need to correlate expression levels and phenotypic
openaire +3 more sources
Vitamin A and regulation of gene expression
Current Opinion in Clinical Nutrition and Metabolic Care, 1998The biologically active form of vitamin A, retinoic acid, and its synthetic analogs exhibit potent anti-proliferative normalization of differentiation and anti-inflammatory activities, which appear to account for their therapeutic effects in hyperproliferative and inflammatory diseases, such as acne, psoriasis, photoaging and neoplasias.
Roshantha A.S. Chandraratna +1 more
openaire +3 more sources
Glucose regulation of gene expression
Current Opinion in Clinical Nutrition and Metabolic Care, 1998Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt to the nutritional environment. In-vivo and in-vitro experiments have demonstrated that the transcription of genes coding for lipogenic and glycolytic enzymes in liver and/or adipose tissue is upregulated by glucose.
Fabienne Foufelle +2 more
openaire +3 more sources
Androgen-Regulated Gene Expression
Annual Review of Physiology, 1989While a great deal of knowledge on the mechanisms of steroid hormone regulated gene expression now exists, specific information relating to androgens is lacking. A number of experimental systems have been developed and show promise as models for molecular studies of androgen regulation.
F G Berger, G Watson
openaire +3 more sources
Regulation of Gene Expression by Glucocorticoids
Annual Review of Physiology, 1989Steroid hormones mediate profound physiological and developmental effects in higher eukaryotes. By interacting with their intracellular receptors in target cells, steroid hormones provide mechanisms for cellular communication and alterations in phenotypic response to environmental and internal stimuli.
Kerry L. Burnstein, John A. Cidlowski
openaire +3 more sources
Biotin — a regulator of gene expression
The Journal of Nutritional Biochemistry, 2005The role of biotin as the prosthetic group of the four biotin-dependent carboxylases in higher organisms is well recognized. Based on the roles of these carboxylases in metabolism, the requirement of biotin for cell viability, growth and differentiation was established. Biotin seems to have a role in cell functions other than as the prosthetic group of
openaire +3 more sources
Gene Expression and Regulation
2014In this chapter we make use of all the material studied so far to construct a few (simple but informative) models for gene expression. As before, we are interested in obtaining useful information regarding both the dynamical and thermodynamical aspects of this phenomenon.
openaire +2 more sources