Results 61 to 70 of about 2,699,650 (306)

Pharmacological regulation of gene expression [PDF]

Pharmacological Research, 2011
Pharmacological regulation of gene expression was one of the top professional interests of Dr. Costa. He promoted the idea that drugs can improve the endogenous mechanisms of synaptic plasticity by modulating gene expression. In this article I reflect upon Dr.
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Differential expression analysis with global network adjustment [PDF]

, 2013
<p>Background: Large-scale chromosomal deletions or other non-specific perturbations of the transcriptome can alter the expression of hundreds or thousands of genes, and it is of biological interest to understand which genes are most profoundly ...
A Antonellis, A Zellner, AE Hoerl, AI Su, D Bates, DB Dahl, E Choy, EJ Cosgrove, H Zou, J Friedman, J Ruan, J Schoumans, J Wettenhall, Jannine D Cody, Jonathan A Gelfond, Joseph G Ibrahim, JT Leek, M Gustafsson, M Newton, Mayetri Gupta, Ming-Hui Chen, R Development Core Team, R Tibshirani, RJ Prill, S Pounds, SC Smith, SM Siepka, T Barrett, T Barrett   +28 more
core   +3 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Balancing noise and plasticity in gene expression [PDF]

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Djordje Bajic, Juan F. Poyatos
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli [PDF]

, 2010
The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN
A Travers, C Marr, Carsten Marr, DP Sangurdekar, E Krause, Fabian J. Theis, G Balázsi, H Yu, J Vogel, J Ward Jr, JD Glasner, JJ Faith, Larry S. Liebovitch, M. Madan Babu, Marc-Thorsten Hütt, MJ Herrgard, N Blot, N Sonnenschein, NM Luscombe, O Alter, Q Cui, R Milo, R Milo, RM Gutierrez-Rios, S Gama-Castro, S Gottesman, S Mangan, S Mangan, S Mangan, SS Shen-Orr, T Beissbarth, VG Tusher   +31 more
core   +5 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Atlas: automatic modeling of regulation of bacterial gene expression and metabolism using rule-based languages [PDF]

, 2020
Rodrigo Santibáñez, Daniel Garrido, Alberto J. M. Martín   +2 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source