Results 61 to 70 of about 2,701,308 (189)

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

Nature Communications, 2018
CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor ...
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang   +14 more
doaj   +1 more source

Optimising the IgG‐degrading enzyme treatment regimen for enhanced adeno‐associated virus transduction in the presence of neutralising antibodies

Clinical & Translational Immunology, 2022
Objective Pre‐existing neutralising antibodies (NAbs) to adeno‐associated viruses (AAVs) remain an impediment for systemically administered AAV‐mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome ...
Irene Ros‐Gañán, Mirja Hommel, Laia Trigueros‐Motos, Blanche Tamarit, Estefanía Rodríguez‐García, David Salas, Guiomar Pérez, Anne Douar, Jean Philippe Combal, Bernard Benichou, Veronica Ferrer, Gloria González‐Aseguinolaza   +11 more
doaj   +1 more source

Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure

Frontiers in Genetics, 2021
A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Oleg V. Bylino, Airat N. Ibragimov, Airat N. Ibragimov, Anna E. Pravednikova, Yulii V. Shidlovskii, Yulii V. Shidlovskii   +5 more
doaj   +1 more source

Differential expression analysis with global network adjustment [PDF]

, 2013
<p>Background: Large-scale chromosomal deletions or other non-specific perturbations of the transcriptome can alter the expression of hundreds or thousands of genes, and it is of biological interest to understand which genes are most profoundly ...
A Antonellis, A Zellner, AE Hoerl, AI Su, D Bates, DB Dahl, E Choy, EJ Cosgrove, H Zou, J Friedman, J Ruan, J Schoumans, J Wettenhall, Jannine D Cody, Jonathan A Gelfond, Joseph G Ibrahim, JT Leek, M Gustafsson, M Newton, Mayetri Gupta, Ming-Hui Chen, R Development Core Team, R Tibshirani, RJ Prill, S Pounds, SC Smith, SM Siepka, T Barrett, T Barrett   +28 more
core   +3 more sources

Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions

Pathogens, 2015
Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions.
Rafael Aldabe, Lester Suárez-Amarán, Carla Usai, Gloria González-Aseguinolaza   +3 more
doaj   +1 more source

ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses

Frontiers in Immunology, 2022
The study of the interferon (IFN) α-induced cell transcriptome has shown altered expression of several long non-coding RNAs (lncRNAs). ISR8/IRF1-AS1 (IFN stimulated RNA 8), located close to IFN regulatory factor 1 (IRF1) coding gene, transcribes a lncRNA
Marina Barriocanal, Laura Prats-Mari, Nerea Razquin, Celia Prior, Juan Pablo Unfried, Puri Fortes, Puri Fortes, Puri Fortes, Puri Fortes   +8 more
doaj   +1 more source

Decrease in gyrase A protein expression in _E. coli_ cells inhibited by antisense ribozymes [PDF]

, 2008
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies represent promising strategies for specific inhibition of
Malathi Raghunathan, Shilpakala Sainath Rao   +1 more
core   +1 more source

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]

, 2016
open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M., Connor, Viv, Efstathiou, Stacey, Hann, William, Harman, Laura E.R., Nicoll, Michael P., Proenca, Joao T., Shivkumar, Maitreyi   +7 more
core   +3 more sources

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Nature Communications, 2019
Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber, Leticia Odriozola, Javier Martínez-García, Veronica Ferrer, Anne Douar, Bernard Bénichou, Gloria González-Aseguinolaza, Cristian Smerdou   +7 more
doaj   +1 more source

The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II

Cell Reports, 2018
Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear cell
Marco Trizzino, Elisa Barbieri, Ana Petracovici, Shuai Wu, Sarah A. Welsh, Tori A. Owens, Silvia Licciulli, Rugang Zhang, Alessandro Gardini   +8 more
doaj   +1 more source