Results 91 to 100 of about 1,687,286 (315)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A never-ending story: the steadily growing family of the FA and FA-like genes [PDF]

, 2017
Anna Gueiderikh, Filippo Rosselli, Januario Bispo Cabral Neto   +2 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Genome-wide identification, characterization, and evolutionary analysis of the barley TALE gene family and its expression profiles in response to exogenous hormones

Frontiers in Plant Science
Three-amino-loop-extension (TALE) family belongs to the homeobox gene superfamily and occurs widely in plants, playing a crucial role in regulating their growth and development.
Tian-jiang Liao, Tian-jiang Liao, Tao Huang, Hui-yan Xiong, Jie-cuo Duo, Jie-cuo Duo, Jian-zhi Ma, Ming-yang Du, Rui-jun Duan, Rui-jun Duan   +9 more
doaj   +1 more source

The MAPKKK and MAPKK gene families in banana: identification, phylogeny and expression during development, ripening and abiotic stress [PDF]

, 2017
Lianzhe Wang, Wei Hu, Weiwei Tie, Zehong Ding, Xupo Ding, Yang Liu, Yan Yan, Chunlai Wu, Ming Peng, Biyu Xu, Zhiqiang Jin   +10 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Evolutionary and expression analysis of CAMTA gene family in Nicotiana tabacum yielded insights into their origin, expansion and stress responses [PDF]

, 2018
Kaleem U. Kakar, Zarqa Nawaz, Zhouqi Cui, Peijian Cao, Jingjing Jin, Qingyao Shu, Xueliang Ren   +6 more
openalex   +1 more source

Identification of a Prognostic Signature Associated With the Homeobox Gene Family for Bladder Cancer

, 2021
Bingqi Dong, Jiaming Liang, Li Ding, Wenping Song, Jinbo Song, Mingkai Zhu, Shiming Zhao, Yongkang Ma, Tiejun Yang   +8 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Whole‐exome sequencing of nevoid basal cell carcinoma syndrome families and review of Human Gene Mutation Database PTCH1 mutation data [PDF]

, 2018
D. Matthew Gianferante, Melissa Rotunno, Michael Dean, Weiyin Zhou, Belynda Hicks, Katrina Wyatt, Kristine Jones, Mingyi Wang, Bin Zhu, Alisa M. Goldstein, Kari G. Rabe   +10 more
openalex   +1 more source