Results 101 to 110 of about 11,121,866 (385)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A Comprehensive Analysis of the Peanut SQUAMOSA Promoter Binding Protein-like Gene Family and How AhSPL5 Enhances Salt Tolerance in Transgenic Arabidopsis

Plants
SPL (SQUAMOSA promoter binding protein-like), as one family of plant transcription factors, plays an important function in plant growth and development and in response to environmental stresses. Despite SPL gene families having been identified in various
Xiaohui Sun, Lili Zhang, Weihua Xu, Jianpeng Zheng, Meiling Yan, Ming Zhao, Xinyu Wang, Yan Yin   +7 more
doaj   +1 more source

MYB Transcription Factors in Chinese Pear (Pyrus bretschneideri Rehd.): Genome-Wide Identification, Classification and Expression Profiling during Fruit Development

Frontiers in Plant Science, 2016
The MYB family is one of the largest families of transcription factors in plants. Although some MYBs have been reported to play roles in secondary metabolism, no comprehensive study of the MYB family in Chinese pear (Pyrus bretschneideri Rehd.) has been ...
Yun Peng eCao, Yahui eHan, Dahui eLi, Yi eLin, Yongping eCai   +4 more
doaj   +1 more source

MCScanX: a toolkit for detection and evolutionary analysis of gene synteny and collinearity

Nucleic Acids Research, 2012
MCScan is an algorithm able to scan multiple genomes or subgenomes in order to identify putative homologous chromosomal regions, and align these regions using genes as anchors.
Yupeng Wang, Haibao Tang, Jeremy D. DeBarry, Xu Tan, Jingping Li, Xiyin Wang, Tae-Ho Lee, Huizhe Jin, Barry S. Marler, Hui Guo, J. Kissinger, A. Paterson   +11 more
semanticscholar   +1 more source

Characterization of the FAM110 gene family

Genomics, 2007
We have previously characterized the centrosome/spindle pole-associated protein (CSPP) involved in cell cycle progression. The open reading frame C20orf55 was identified in a yeast two-hybrid screen in a search for CSPP-interacting proteins. A homology search revealed that C20orf55 belongs to a gene family consisting of three members that have not yet ...
Helena Hauge, Hans Christian Aasheim, Sebastian Patzke   +2 more
openaire   +3 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Identification and expression profiling of SmGATA genes family involved in response to light and phytohormones in eggplant

Frontiers in Plant Science
GATA proteins are transcription factors of zinc finger proteins, which play an important role in plant growth development and abiotic stress. However, there have been no identification or systematic studies of the GATA gene family in eggplant.
Yanyan Wang, Xinyun Li, Yunrong Mo, Caiqian Jiang, Ying Zhou, Jingyi Hu, Youling Zhang, Junheng Lv, Kai Zhao, Zhenya Lu   +9 more
doaj   +1 more source

A large family of AvrLm6-like genes in the apple and pear scab pathogens, Venturia inaequalis and Venturia pirina

Frontiers in Plant Science, 2015
Venturia inaequalis and V. pirina are Dothideomycete fungi that cause apple scab and pear scab disease respectively. Whole genome sequencing of V. inaequalis and V.
Jason eShiller, Angela P Van de Wouw, Adam eTaranto, Adam eTaranto, Joanna K Bowen, David eDubois, Andrew eRobinson, Andrew eRobinson, Cecilia H Deng, Kim Marilyn Plummer   +9 more
doaj   +1 more source

The pattern and process of gene family evolution [PDF]

arXiv, 2011
Large scale databases are available that contain homologous gene families constructed from hundreds of complete genome sequences from across the three domains of Life. Here we discuss approches of increasing complexity aimed at extracting information on the pattern and process of gene family evolution from such datasets.
arxiv  

The human protein disulfide isomerase gene family

Human Genomics, 2012
Enzyme-mediated disulfide bond formation is a highly conserved process affecting over one-third of all eukaryotic proteins. The enzymes primarily responsible for facilitating thiol-disulfide exchange are members of an expanding family of proteins known ...
J. Galligan, D. Petersen
semanticscholar   +1 more source