Results 171 to 180 of about 1,724,839 (265)

Sucrose synthase gene family analysis in loquat reveals <i>EjSUS4</i> as a key regulator of sugar accumulation. [PDF]

Front Plant Sci
Yan J, Shao W, Ding J, Chen M, Yang C, Xu K, Wu B.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Functional Analysis of MADS-Box Gene Family in Stress Response and Prospects of Breeding Application. [PDF]

Plants (Basel)
Wang J, Wang H, Li M, Chen Y, Song B, Li Y, Meng X, Li J, Lu W, Gao Y, Zhang Y, Wang A.   +11 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Coordinated gene family evolution shapes the genome of dimorphic Mucorales. [PDF]

Nat Commun
Tahiri G, Navarro-Mendoza MI, Lax C, Pérez-Arques C, Saz GN, Navarro E, Garre V, Nicolás FE.   +7 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Expansion of the geranylgeranyl pyrophosphate synthase gene family underlies the evolution of terpenoid biosynthesis in termites. [PDF]

PLoS Biol
Horáček N, Lukšan O, Rebholz Z, Harant K, Pohl R, Mutabdžija-Nedelcheva L, Hellemans S, Jungwirth D, Křivánek J, Amirianová A, Kyjaková P, Bourguignon T, Tholl D, Hanus R, Štáfková J.   +14 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Characterization, evolutionary analysis, and expression profiling of the <i>VrPYL</i> gene family in mung bean in response to abiotic stress. [PDF]

PeerJ
Yin L, Xiao Y, Liao J, Zhang D, Chen X.
europepmc   +1 more source