Results 271 to 280 of about 1,883,452 (313)

Gene Structure and Gene Families

2019
Approaches for the discovery of protein-coding genes were described in detail in Chap. 3. These included EST sequencing, RNA-seq, and full genome sequencing. Raw DNA sequences generated by these approaches are assembled into sets that are assumed to come from a single genetic locus. These are often called unigene sets.
David B. Neale, Nicholas C. Wheeler
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Family reunion – The ZIP/prion gene family

Progress in Neurobiology, 2011
Prion diseases are fatal neurodegenerative diseases of humans and animals which, in addition to sporadic and familial modes of manifestation, can be acquired via an infectious route of propagation. In disease, the prion protein (PrP(C)) undergoes a structural transition to its disease-causing form (PrP(Sc)) with profoundly different physicochemical ...
Sepehr, Ehsani, Hairu, Huo, Ashkan, Salehzadeh, Cosmin L, Pocanschi, Joel C, Watts, Holger, Wille, David, Westaway, Ekaterina, Rogaeva, Peter H, St George-Hyslop, Gerold, Schmitt-Ulms   +9 more
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Genes and family environment in familial clustering of cancer

Theoretical Medicine, 1994
Familial clustering of a disease is defined as the occurrence of the disease within some families in excess of what would be expected from the occurrence in the population. It has been demonstrated for several cancer types, ranging from rare cancers as the adenomatosis-coli-associated colon cancer or the Li-Fraumeni syndrome to more common cancers as ...
K, Borch-Johnsen, J H, Olsen, T I, Sørensen   +2 more
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Evolution of the spermadhesin gene family

Gene, 2005
Spermadhesins belong to a novel family of secretory proteins of the male genital tract. They are major proteins of the seminal plasma and have been found peripherally associated to the sperm surface. So far, they have only been detected in ungulates, specifically in pig, cattle, and horse, respectively.
Bianca, Haase, Christian, Schlötterer, Mahnaz Ekhlasi, Hundrieser, Heidi, Kuiper, Ottmar, Distl, Edda, Töpfer-Petersen, Tosso, Leeb   +6 more
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The evolution of the thrombospondin gene family

Journal of Molecular Evolution, 1993
Thrombospondin-1 is an adhesive glycoprotein that is involved in cellular attachment, spreading, migration, and proliferation. To date, four genes have been identified that encode for the members of the thrombospondin gene family. These four genes are homologous to each other in the EGF-like (type 2) repeats, the calcium-binding (type 3) motifs, and ...
J, Lawler, M, Duquette, L, Urry, K, McHenry, T F, Smith   +4 more
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The mouse cornichon gene family

Development Genes and Evolution, 1999
As part of a large scale mouse Expressed Sequence Tag (EST) project to identify molecules involved in the initiation of mammalian development, a homolog of the Drosophila cornichon gene was detected as a mouse maternal transcript present in the two-cell embryo.
Hwang, S Y, Oh, B, Zhang, Z, Miller, W, Solter, D, Knowles, B B   +5 more
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The insect SNMP gene family

Insect Biochemistry and Molecular Biology, 2009
SNMPs are membrane proteins observed to associate with chemosensory neurons in insects; in Drosophila melanogaster, SNMP1 has been shown to be essential for the detection of the pheromone cis-vaccenyl acetate (CVA). SNMPs are one of three insect gene clades related to the human fatty acid transporter CD36.
Richard G, Vogt, Natalie E, Miller, Rachel, Litvack, Richard A, Fandino, Jackson, Sparks, Jon, Staples, Robert, Friedman, Joseph C, Dickens   +7 more
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The paraoxonase gene family and atherosclerosis

Free Radical Biology and Medicine, 2005
Epidemiologic, genetic, and biochemical studies support an antiatherogenic role for paraoxonase (PON) 1. While the precise mechanism by which PON1 protects against the development of atherosclerosis is unclear, in vitro studies and the results from PON1 knockout and transgenic mice suggest that this protective effect may be attributed to PON1's ability
Carey J, Ng, Diana M, Shih, Susan Y, Hama, Natividad, Villa, Mohamad, Navab, Srinivasa T, Reddy   +5 more
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The connexin gene family in mammals

Biological Chemistry, 2005
Unannotated mammalian genome databases (dog, cow, opossum) were searched for candidate connexin genes, using sequences from annotated genomes (man, mouse). All 18 'multi-species' connexin genes, i.e., orthologs of connexin26 , 29/31.3 (duplicated in opossum), 30, 30.2/31.9, 30.3, 31, 31.1, 32, 36, 37, 39/40.1, 40, 43, 45, 44/46, 47, 50, and 57/62 ...
Véronique, Cruciani, Svein-Ole, Mikalsen   +1 more
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Gene factories, microfunctionalization and the evolution of gene families

Trends in Genetics, 2005
Gene duplication has long been considered an important force in genome evolution. In this article, I consider families of tandemly duplicated genes that show 'microfunctionalization' - genes encoding similar proteins with subtly different functions, such as olfactory receptors.
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