Results 71 to 80 of about 11,121,866 (385)

NFAT gene family in inflammation and cancer.

Current molecular medicine, 2013
Calcineurin-NFAT signaling is critical for numerous aspects of vertebrate function during and after embryonic development. Initially discovered in T cells, the NFAT gene family, consisting of five members, regulates immune system, inflammatory response ...
M. G. Pan, Yiqin Xiong, Feng Chen
semanticscholar   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Genome-Wide Identification and Expression Profiles of Myosin Genes in the Pacific White Shrimp, Litopenaeus vannamei

Frontiers in Physiology, 2019
As the main structural protein of muscle fiber, myosin is essential for multiple cellular processes or functions, especially for muscle composition and development.
Xiaoxi Zhang, Xiaoxi Zhang, Xiaoxi Zhang, Jianbo Yuan, Jianbo Yuan, Jianbo Yuan, Xiaojun Zhang, Xiaojun Zhang, Xiaojun Zhang, Chengzhang Liu, Chengzhang Liu, Chengzhang Liu, Fuhua Li, Fuhua Li, Fuhua Li, Jianhai Xiang, Jianhai Xiang, Jianhai Xiang   +17 more
doaj   +1 more source

Genome-Wide Identified MADS-Box Genes in Prunus campanulata ‘Plena’ and Theirs Roles in Double-Flower Development

Plants, 2023
The MADS-box gene family plays key roles in flower induction, floral initiation, and floral morphogenesis in flowering plants. To understand their functions in the double-flower formation of Prunus campanulata ‘Plena’ (hereafter referred to as PCP ...
Chaoren Nie, Xiaoguo Xu, Xiaoqin Zhang, Wensheng Xia, Hongbing Sun, Na Li, Zhaoquan Ding, Yingmin Lv   +7 more
doaj   +1 more source

Evolutionary history of the UCP gene family: gene duplication and selection [PDF]

BMC Evol. Biol. 8 (2008) 306, 2008
BACKGROUND: The uncoupling protein (UCP) genes belong to the superfamily of electron transport carriers of the mitochondrial inner membrane. Members of the uncoupling protein family are involved in thermogenesis and determining the functional evolution of UCP genes is important to understand the evolution of thermo-regulation in vertebrates.
arxiv   +1 more source

Gene family evolution in green plants with emphasis on the origination and evolution of Arabidopsis thaliana genes.

The Plant Journal, 2013
Gene family size variation is an important mechanism that shapes the natural variation for adaptation in various species. Despite its importance, the pattern of gene family size variation in green plants is still not well understood.
Ya-long Guo
semanticscholar   +1 more source

The human crystallin gene families [PDF]

Human Genomics, 2012
Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins. During evolution, other proteins have sometimes been recruited as crystallins to modify the properties of the lens.
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Comprehensive Genomic Analysis and Expression Profile of Hsp70 Gene Family Related to Abiotic and Biotic Stress in Cucumber

Horticulturae, 2023
Heat shock protein 70 (Hsp70) is a class of HSPs involved in plant growth and development, stress response and regulation. The Hsp70 proteins exist widely in the plant world, but the detail information about Hsp70s is still unclear in cucumber.
Zixian Zhou, Lingdi Xiao, Jindong Zhao, Zhaoyang Hu, Yuelong Zhou, Shiqiang Liu, Hao Wu, Yong Zhou   +7 more
doaj   +1 more source

Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family

PLoS ONE, 2013
In mammals, IFIT (Interferon [IFN]-induced proteins with Tetratricopeptide Repeat [TPR] motifs) family genes are involved in many cellular and viral processes, which are tightly related to mammalian IFN response.
Y. Liu, Yi-Bing Zhang, Ting-kai Liu, J. Gui   +3 more
semanticscholar   +1 more source