Results 81 to 90 of about 11,121,866 (385)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Genome-Wide Identification and Evolutionary Analysis of Gossypium YTH Domain-Containing RNA-Binding Protein Family and the Role of GhYTH8 in Response to Drought Stress

Plants, 2023
YTH domain-containing proteins are one kind of RNA-binding protein involved in post-transcriptional regulation and play multiple roles in regulating the growth, development, and abiotic stress responses of plants.
Wei Hao, Weipeng Wang, Xiangfen Xiao, Jialiang Sun, Bingjie Wu, Yuping Zhao, Shuaishuai Pei, Wenjia Fan, Dongbei Xu, Tengfei Qin   +9 more
doaj   +1 more source

Orientation of Fitch Graphs and Detection of Horizontal Gene Transfer in Gene Trees [PDF]

arXiv, 2021
Horizontal gene transfer events partition a gene tree $T$ and thus, its leaf set into subsets of genes whose evolutionary history is described by speciation and duplication events alone. Indirect phylogenetic methods can be used to infer such partitions $\mathcal{P}$ from sequence similarity or evolutionary distances without any a priory knowledge ...
arxiv  

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Characterization of hexokinase gene family members in Glycine max and functional analysis of GmHXK2 under salt stress

Frontiers in Genetics, 2023
Hexokinase (HXK) is a bifunctional enzyme involved in carbohydrate metabolism and sugar signal sensing. HXK gene family has been extensively discussed in many species, while the detailed investigations of the family in Glycine max have yet to be reported.
Shuai Chen, Zengyuan Tian, Yuqi Guo
doaj   +1 more source

Conservation and innovation in the DUX4-family gene network

Nature Genetics, 2017
Facioscapulohumeral dystrophy (FSHD; MIM158900, MIM158901) is caused by misexpression of the DUX4 transcription factor in skeletal muscle. Animal models of FSHD are hindered by incomplete knowledge regarding the conservation of the DUX4 transcriptional ...
Jennifer L. Whiddon, Ashlee T. Langford, Chao-Jen Wong, Jun Wen Zhong, S. Tapscott   +4 more
semanticscholar   +1 more source

The DMRT gene family in amphioxus

Journal of Biomolecular Structure and Dynamics, 2012
Doublesex and Mab-3-related transcription factor (DMRT) gene family is widely known for its involvement in sex determination and/or differentiation among different phyla. In this study, we identify eight DMRT genes in the cephalochordate amphioxus, a protochordate holding a key phylogenetic position. The eight DMRTs can be divided into two groups based
Hongyan Li, Yang Yu, Dongrui Ji, Fei Wang   +3 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Transcriptome Analysis and Genome-Wide Gene Family Identification Enhance Insights into Bacterial Wilt Resistance in Tobacco

Agronomy
Bacterial wilt, caused by the Ralstonia solanacearum species complex, is one of the most damaging bacterial diseases in tobacco and other Solanaceae crops.
Zhengwen Liu, Zhiliang Xiao, Ruimei Geng, Min Ren, Xiuming Wu, He Xie, Ge Bai, Huifen Zhang, Dan Liu, Caihong Jiang, Lirui Cheng, Aiguo Yang   +11 more
doaj   +1 more source