Results 91 to 100 of about 11,541,343 (347)
Surprisingly Little Population Genetic Structure In A Fungus-Associated Beetle Despite Its Exploitation Of Multiple Hosts [PDF]
, 2013 In heterogeneous environments, landscape features directly affect the structure of genetic variation among populations by functioning as barriers to gene flow.
Brodie, E. D., III +3 more
core +2 more sources
The Himalayas as a Directional Barrier to Gene Flow [PDF]
The American Journal of Human Genetics, 2007 High-resolution Y-chromosome haplogroup analyses coupled with Y-short tandem repeat (STR) haplotypes were used to (1) investigate the genetic affinities of three populations from Nepal--including Newar, Tamang, and people from cosmopolitan Kathmandu (referred to as "Kathmandu" subsequently)--as well as a collection from Tibet and (2) evaluate whether ...
Alicia M. Cadenas +8 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Landscape genetics and gene flow in the banana pathogenic fungus Mycosphaerella fijiensis [PDF]
, 2007 Among the different evolutionary forces driving population genetics, gene flow related to dispersal plays a major role in local adaptation processes. However very few studies on plant pathogenic fungi focussed on deciphering gene flow patterns at the ...
Carlier, Jean +7 more
core
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Ecology and Evolution, 2021 Ecological, environmental, and geographic factors all influence genetic structure. Species with broad distributions are ideal systems because they cover a range of ecological and environmental conditions allowing us to test which components predict ...
Catherine A. Welke +4 more
doaj +1 more source
Frontiers in Plant Science, 2021 Leaf shape exhibits tremendous diversity in angiosperms. It has long been argued that leaf shape can affect major physiological and ecological properties of plants and thus is likely to be adaptive, but the evolutionary evidence is still scarce ...
Hui Wang +5 more
doaj +1 more source
Inconsistency of Species Tree Methods under Gene Flow.
Systematic Biology, 2016 Coalescent-based methods are now broadly used to infer evolutionary relationships between groups of organisms under the assumption that incomplete lineage sorting (ILS) is the only source of gene tree discordance.
Claudia R. Solís-Lemus +2 more
semanticscholar +1 more source
Cross-talk and interference enhance information capacity of a signaling pathway [PDF]
Biophysical Journal 104 (2013) 1170-1180, 2012 A recurring motif in gene regulatory networks is transcription factors (TFs) that regulate each other, and then bind to overlapping sites on DNA, where they interact and synergistically control transcription of a target gene. Here, we suggest that this motif maximizes information flow in a noisy network.
arxiv +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source