Results 121 to 130 of about 1,078,640 (312)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Assisted gene flow from outcrossing shows the potential for genetic rescue in an endangered salmon population [PDF]

, 2022
Kasey C. Pregler, Mariska Obedzinski, Elizabeth A. Gilbert‐Horvath, Benjamin White, Stephanie M. Carlson, John Carlos Garza   +5 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Economic weights of maternal and direct traits of pigs calculated by applying gene flow methods

, 2018
M. Wolfová, E. Krupa, Z. Krupová, Eliška Žáková   +3 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Peer Review #1 of "Genetic diversity in Oryza glumaepatula wild rice populations in Costa Rica and possible gene flow from O. sativa (v0.2)"

, 2016
Eric J. Fuchs, Allan Meneses Martínez, Amanda Calvo, Melania Muñoz, Griselda Arrieta-Espinoza, Allan Meneses, M Akimoto, Y Shimamoto, H Morishima, D Brar, Rpv Brondani, M Zucchi, C Brondani, Phn Rangel, Tcdo Borba, P Rangel, M Magalhes, R Vencovsky, Gsc Buso, P Rangel, M Ferreira, L Chen, D Lee, Z Song, H Suh, B Lu, D Chen, P Ronald, Y-E Chu, H-I Oka, N Ellstrand, N Ellstrand, H Prentice, J Hancock, G Evanno, S Regnaut, J Goudet, R Frankham, R Hajjar, T Hodgkin, J Hamrick, Mjw Godt, K Holsinger, P Lewis, D Dey, K Holsinger, L Wallace, M Jakobsson, N Rosenberg, Z Jiang, H Xia, B Basso, B-R Lu, Z Kamvar, J Tabima, N Grnwald, Mmg Karasawa, R Vencovsky, C Silva, M Zucchi, Gcx Oliveira, E Veasey, Mmg Karasawa, R Vencovsky, C Silva, D Cardim, A Bressan E De, Gcx Oliveira, E Veasey, G Khush, J Lomas, H Herrera, B-R Lu, B-R Lu, A Snow, R Mack, W Lonsdale, R Nathan, F Schurr, O Spiegel, O Steinitz, A Trakhtenbrot, A Tsoar, D Newman, D Pilson, R Peakall, P Smouse, Bja Pollux, Mde Jong, A Steegh, E Verbruggen, J Van Groenendael, N Ouborg, E Sanchez-Olguin, G Arrieta-Espinoza, J Lobo, A Espinoza-Esquivel, A Snow, Z Song, B-R Lu   +99 more
openalex   +2 more sources

Gene Flow or Heterozygote Advantage? [PDF]

Science, 1994
D, Berrigan, J, Evans, D, Holway, L, Jacobs, M, Richards, J, Seger   +5 more
openaire   +3 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source