FREQUENCY OF NRAS AND KRAS GENES IN NEWLY DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS
Objective: To determine the frequency of NRAS and KRAS mutations in newly diagnosed acute myeloid leukemia patients and correlation with their clinicopathological parameters along with prognostic impact. Study Design: Cross-sectional study.
Sidra Barlas +5 more
doaj
Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system. [PDF]
BACKGROUND: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. METHODS: In this study, the acute effects of recovery between mild head injuries and the frequency of ...
Assari, Soroush +4 more
core +2 more sources
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution
Santanu Biswas +5 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Gene-Mating Dynamic Evolution Theory II: Global stability of N-gender-mating polyploid systems
Extending the previous 2-gender dioecious diploid gene-mating evolution model [arXiv:1410.3456], we attempt to answer "whether the Hardy-Weinberg global stability and the exact analytic dynamical solutions can be found in the generalized N-gender N ...
Wang, Juven
core +1 more source
Identifying interactions in the time and frequency domains in local and global networks : a Granger causality approach [PDF]
Background Reverse-engineering approaches such as Bayesian network inference, ordinary differential equations (ODEs) and information theory are widely applied to deriving causal relationships among different elements such as genes, proteins, metabolites,
Feng, Jianfeng +3 more
core +4 more sources
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Background The study aimed to investigate the influence of extremely low-frequency electromagnetic fields (ELF-EMF) on clear cell renal cell carcinoma (ccRCC) by assessing alterations in gene expression and the secretion of cytokines and chemokines ...
Aleksandra Cios +7 more
doaj +1 more source
The infinitely many genes model with horizontal gene transfer
The genome of bacterial species is much more flexible than that of eukaryotes. Moreover, the distributed genome hypothesis for bacteria states that the total number of genes present in a bacterial population is greater than the genome of every single ...
Baumdicker, Franz, Pfaffelhuber, Peter
core +1 more source

