Results 161 to 170 of about 1,747,624 (329)

Estimation of prokaryotic supergenome size and composition from gene frequency distributions. [PDF]

BMC Genomics, 2014
Lobkovsky AE, Wolf YI, Koonin EV.
europepmc   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Gene frequency distributions reject a neutral model of genome evolution. [PDF]

Genome Biol Evol, 2013
Lobkovsky AE, Wolf YI, Koonin EV.
europepmc   +1 more source

FREQUENCY OF DELETERIOUS CHROMOSOMES AND ALLELISM BETWEEN LETHAL GENES IN JAPANESE NATURAL POPULATIONS OF <i>DROSOPHILA MELANOGASTER</i>

, 1969
Takao Watanabe
openalex   +2 more sources

Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy. [PDF]

, 1978
John Pearn
openalex   +1 more source

Gene frequencies in Boston's cats [PDF]

Heredity, 1964
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy

BMC Neurology
Background This study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high seizure frequency refractory temporal lobe epilepsy (TLE). Methods A consecutive series of patients with
Ryan Sprissler, Michael Hammer, David Labiner, Neil Joshi, Albert Alan, Martin Weinand   +5 more
doaj   +1 more source

Effect of Artificial Insemination on Frequency of Undesirable Recessive Genes

, 1967
L.D. Van Vleck
openalex   +1 more source