Results 221 to 230 of about 1,747,624 (329)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Landscape of rare-allele variants in cultivated and wild soybean genomes. [PDF]

Plant Genome
Liu Z, Shi X, Yang Q, Li Y, Yang C, Zhang M, An YC, Nguyen HT, Yan L, Song Q.   +9 more
europepmc   +1 more source

Frequency analysis of functional immunoglobulin C and V gene expression in murine B cells at various ages. [PDF]

, 1983
Herbert Hooijkaas, A.A. Preesman, A. van Oudenaren, R. Benner, J.J. Haaijman   +4 more
openalex   +1 more source

Sex and frequency of gene conversions in meiosis [PDF]

Nature, 1985
openaire   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Generative artificial intelligence, integrative bioinformatics, and single-cell analysis reveal Alzheimer's genetic and immune landscape. [PDF]

Mol Ther Nucleic Acids
Das A, Bhattacharya M, Abdelhameed AS, Lee SS, Chakraborty C.   +4 more
europepmc   +1 more source

Determining the prevalence of McArdle disease from gene frequency by analysis of next-generation sequencing data. [PDF]

Genet Med, 2015
De Castro M, Johnston J, Biesecker L.
europepmc   +1 more source

INCREASED FREQUENCY OF THE BfF GENE IN THE IDIOPATHIC NEPHROTIC SYNDROME (INS): STUDIES OF THE ALTERNATIVE COMPLEMENT PATHWAY IN INS [PDF]

, 1980
R H McLean, T. L. Kennedy, Mark Ballow, Norman J. Siegel   +3 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model. [PDF]

Commun Med (Lond)
Benamer N, Le Ribeuz H, Felgerolle C, Calvet C, Postal O, Plion B, Saenz-Roldan M, Giorgi M, Lecomte MJ, Nguyen Y, Petit C, Michalski N, Gourévitch B, Akil O, Safieddine S.   +14 more
europepmc   +1 more source