Results 221 to 230 of about 13,199,223 (392)

Effect of misspecification of gene frequency on the two-point LOD score

European Journal of Human Genetics, 2001
D. Pal, M. Durner, D. Greenberg
semanticscholar   +1 more source

Pilot Study of Preconception Carrier Screening in Russia: Initial Findings and Challenges. [PDF]

Genes (Basel)
Glotov AS, Nasykhova YA, Lazareva TE, Dvoynova NM, Shabanova ES, Danilova MM, Osinovskaya NS, Barbitoff YA, Maretina MA, Gorodnicheva EE, Tonyan ZN, Kiselev AV, Basipova AA, Bespalova ON, Kogan IY.   +14 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model. [PDF]

Clin Transl Med
Iranfar S, Bagur S, Felgerolle C, Cornille M, Benamer N, Ribeuz HL, Giorgi M, Jamali S, Saoudi A, Lecomte MJ, Michel V, Bathellier B, Safieddine S.   +12 more
europepmc   +1 more source

SELECTION FOR RATE OF DEVELOPMENT AND GENE ARRANGEMENT FREQUENCIES IN DROSOPHILA PERSIMILIS [PDF]

, 1964
Eliot B. Spiess, Luretta D. Spiess
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Redistribution of Gene Frequency and Changes of Genetic Variation Following a Bottleneck in Population Size

Genetics, 2004
Xu‐Sheng Zhang, Jinliang Wang, W. G. Hill   +2 more
semanticscholar   +1 more source

JoGo 1.0: the ACTG hierarchical nomenclature and database covering 4.7 million haplotypes across 19,194 human genes. [PDF]

Nucleic Acids Res
Nagasaki M, Katayama T, Moriya Y, Sekiya Y, Kawashima S, Teraoka R, Machida S, Matsubara T, Hashimoto H, Asakura A, Nagano A, Yamashita R, Takada T, Mitsuhashi N, Kamada M, Ohkawa Y, Tokunaga K, Kawai Y, Variant Information Standardization Collegium .   +18 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Frequency of Three Hemochromatosis Gene Mutations in Antalya, Turkey

Balkan Journal of Medical Genetics, 2007
Oztürk S, Lüleci G, Keser I
doaj   +1 more source