Results 241 to 250 of about 13,063,295 (390)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Mutational landscape of gastrointestinal stromal tumors using next-generation sequencing of a 73-gene panel. [PDF]

World J Surg Oncol
Wang C, Cheng B, Yang S, Yin H, Xiong Y, Chen R, Wu Y, Wang C, Wang B, Gao Z, Ye Y.   +10 more
europepmc   +1 more source

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

Circular single stranded DNA potentiates non-viral gene insertion in hematopoietic stem and progenitor cells. [PDF]

Nat Commun
Letort G, Duclert A, Le Clerre D, Chion-Sotinel I, Salvatori R, Dessez E, Sevin M, Rotondi M, Ducani C, Duchateau P, Valton J.   +10 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Spatial and Temporal Patterns of Prion Gene Variation Are Consistent With a Response to Chronic Wasting Disease-Induced Selection in Wild White-Tailed Deer. [PDF]

Ecol Evol
Bubac CM, Russell T, McKenzie D, Ball MC, Pybus MJ, Coltman DW, Cullingham CI.   +6 more
europepmc   +1 more source

U-shaped gene frequency distributions [PDF]

Nature, 1977
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A colorful legacy of hybridization in wood-warblers includes frequent sharing of carotenoid genes among species and genera. [PDF]

PLoS Biol
Bennett KFP, Wood AW, Baiz MD, Phung LN, Lovette IJ, Toews DPL.   +5 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source