Results 251 to 260 of about 11,790,132 (329)

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

Comparison of genetic mutations in bladder cancers that arose following radiotherapy for prostate cancer with those in primary bladder cancers. [PDF]

Sci Rep
Adomi S, Sakai K, Kura Y, De Velasco MA, Fujimoto S, Toyoda S, Hashimoto M, Nishimoto M, Banno E, Saito Y, Sugimoto K, Hayashi Y, Minami T, Yoshimura K, Uemura H, Nishio K, Fujita K.   +16 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Association between vitamin D receptor gene variants and the risk of type 2 diabetes mellitus in a Ghanaian population. [PDF]

Sci Rep
Arhin-Aidoo F, Fondjo LA, Obirikorang C, Owiredu EW, Senu E, Agomuo SKS, Laing EF.   +6 more
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Association of ATP-binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer. [PDF]

Physiol Rep
Alanazi AH, Shenoy N, Somanath PR.
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Prevalence of Plasmodium falciparum parasites harbouring chloroquine-resistant but not artemisinin-resistant alleles in Busia County, Western Kenya. [PDF]

Malar J
Onchieku NM, Gesusu N, Caspar E, Karani L, Thiong'o K, Kamau L, Kiboi D, Thiebaut L, Ma L, Kimani F, Matoke-Muhia D, Ménard D.   +11 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD. [PDF]

J Neurodev Disord
Zhong Y, Baum LW, Tubbs JD, Ye R, Chen LH, Wu T, Hung SF, Tang CP, Ho TP, Moyzis R, Swanson J, Lee CC, Sham PC, Leung PWL.   +13 more
europepmc   +1 more source