Results 81 to 90 of about 1,747,624 (329)
Detecting signatures of balancing selection to identify targets of anti-parasite immunity.
, 2010 Parasite antigen genes might evolve under frequency-dependent immune selection. The distinctive patterns of polymorphism that result can be detected using population genetic methods that test for signatures of balancing selection, allowing genes encoding
Conway, David J, Weedall, Gareth D
core +1 more source
Listen to genes : dealing with microarray data in the frequency domain [PDF]
, 2009 Background: We present a novel and systematic approach to analyze temporal microarray data. The approach includes normalization, clustering and network analysis of genes.
A Claridge-Chang +32 more
core +3 more sources
UNCORRELATED RANDOM ENVIRONMENTS AND THEIR EFFECTS ON GENE FREQUENCY [PDF]
Evolution, 1974 In the previous paper (Cook and Hartl, 1974) we considered the distribution of gene frequencies in a population evolving in a fluctuating environment when the environmental changes were uncorrelated. In the present article we extend the theory to include autocorrelations in the environment. WVe consider three models. The first (denoted model III in the
Daniel L. Hartl, R. Dennis Cook
openaire +5 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Medycyna PracyBackground The study aimed to investigate the influence of extremely low-frequency electromagnetic fields (ELF-EMF) on clear cell renal cell carcinoma (ccRCC) by assessing alterations in gene expression and the secretion of cytokines and chemokines ...
Aleksandra Cios +7 more
doaj +1 more source
Identifying interactions in the time and frequency domains in local and global networks : a Granger causality approach [PDF]
, 2010 Background Reverse-engineering approaches such as Bayesian network inference, ordinary differential equations (ODEs) and information theory are widely applied to deriving causal relationships among different elements such as genes, proteins, metabolites,
Feng, Jianfeng +3 more
core +4 more sources
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]
, 2017 Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G +2 more
core +3 more sources
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
FREQUENCY OF CALR GENE MUTATION IN MYELOPROLIFERATIVE NEOPLASMS
Pakistan Armed Forces Medical Journal, 2020 Objective: To detect the calreticulin gene mutation in myeloproliferative neoplasms and its clinicohaematological correlation. Study Design: Cross sectional study.
Sana Latif +4 more
doaj