Results 1 to 10 of about 625,164 (166)
Glioblastoma, IDH-wildtype, with a novel MEF2D-NTRK1 gene fusion: a case report [PDF]
Frontiers in OncologyA woman, in her mid-50s, presented with headache, confusion, and unstable gait due to a large right parietal mass subsequently diagnosed histologically as glioblastoma, IDH-wildtype, CNS WHO Grade 4 with an unmethylated MGMT promoter.
Anaya Dewey +7 more
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FuDiCo: Gene Fusion-Initiated Path Propagation for Disease Comorbidity Prediction [PDF]
Current Issues in Molecular BiologyDisease comorbidity—the co-occurrence of two or more diseases in the same individual—has gained growing attention due to its association with adverse clinical outcomes and increased treatment complexity.
Ashwag Altayyar, Li Liao
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Microorganisms, 2022 Microorganisms have a limited and highly adaptable repertoire of genes capable of encoding proteins containing single or variable multidomains. The phytopathogenic bacteria Xanthomonas citri subsp. citri (X.
Amanda C. P. de Oliveira +6 more
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Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours
The Journal of Pathology: Clinical Research, 2023 Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor tyrosine kinase 2 (NTRK2) gene, and its abnormal activation caused ...
Yuehua Li +4 more
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Genomic Features of Solid Tumor Patients Harboring ALK/ROS1/NTRK Gene Fusions
Frontiers in Oncology, 2022 The fusions of receptor tyrosine kinase (RTK) involving anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and neurotrophic receptor tyrosine kinase (NTRK) represent the potential targets of therapeutic intervention for various types of solid ...
Yinghuan Dai +13 more
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Interkingdom gene fusions [PDF]
Genome Biology, 2000 Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another important evolutionary phenomenon involves the evolutionary mobility of protein domains that form versatile multidomain architectures.
Y I, Wolf, A S, Kondrashov, E V, Koonin
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Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli
Open Life Sciences, 2023 Enterotoxigenic Escherichia coli (ETEC) is an important type of pathogenic bacteria that causes diarrhea in humans and young livestock. The pathogen has a high morbidity and mortality rate, resulting in significant economic losses in the pig industry. To
Xu Chongli +6 more
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Chimeric RNA Design Principles for RNA-Mediated Gene Fusion
Cells, 2022 One common genetic alteration in cancer is gene fusion resulting from chromosomal translocations. The mechanisms that create such oncogenic fusion genes are not well understood.
Sachin Kumar Gupta, Laising Yen
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Frontiers in Oncology, 2022 ObjectivesTo test the hypothesis of a relationship between a specific genetic lesion (T2:ERG) and imaging scores, such as PI-RADS and PRI-MUS, and to test the effectiveness of these parameters for the diagnosis of prostate cancer (PCa) and clinically ...
Massimo Lazzeri +26 more
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Frontiers in Genetics, 2022 Background: Synovial sarcoma (SS) is a rare and aggressive cancer that can come from distinct soft tissue types including muscle and ligaments. However, the transcriptomic landscape of SS is still poorly understood.
Zhengwang Sun +6 more
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