Results 41 to 50 of about 3,986,989 (305)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Workshop at Data and Planning Center of NIFS in 2003 "Assesment of Fusion R&D" - The Critical Issues of Demonstration Fusion Reactor - [PDF]

, 2004
実証炉を構想しそれに至る課題を整理することは、核融合研究開発の現状を評価するうえで最も適切な作業のひとつと考えた。磁場閉じ込めと慣性閉じ込め核融合に共通な課題は経済性の改善である。また、磁場閉じ込めではトカマクもヘリカルも将来性のあるダイバータの開発は共通である。 経済性に関しては先進トカマクや高速点火方式のレーザ慣性核融合の提案が出てきている。さらにダイバータに関しては可動型や外置き型の研究が進められている。これらの要約は添付した。In order to asses the fusion ...
TAZIMA, Teruhiko, TAJIMA, Teruhiko, IGUCHI, Harukazu   +2 more
core  

Tropomyosin 3 Gene Fusions in Cancers: From Mechanisms to Treatments—A Comprehensive Review

Cancer Medicine
Background Tropomyosin 3 (TPM3), one of the four tropomyosin genes, is predominantly expressed in eukaryotic cells. As a crucial regulatory protein, TPM3 associates with actin within thin myofilaments, thereby playing an essential role in the regulation ...
Anjie Chen, Sixin Li, Chen Guo, Chenwei Gu, Jiandong Gui, Yujie Deng, Xichen Feng, Yuanyuan Mi   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Constraints on Ion Velocity Distributions from Fusion Product Spectroscopy [PDF]

, 2022
Recent inertial confinement fusion experiments have shown primary fusion spectral moments which are incompatible with a Maxwellian velocity distribution description. These results show that an ion kinetic description of the reacting ions is necessary. We
Hartouni, Edward, Mannion, O.M., Moore, A.S., Taitano, W., Mannion, Owen, Gatu-Johnson, Maria, Appelbe, B.D., Gatu Johnson, Maria, Crilly, Aidan, Appelbe, Brian, Chittenden, Jeremy, Moore, Alastair, Taitano, William, Hartouni, E.P., Chittenden, J.P., Crilly, A.J.   +15 more
core   +1 more source

Spine fusion by gene therapy [PDF]

Gene Therapy, 2004
Over 250 000 patients each year undergo a spine fusion procedure in the US. This constitutes 50% of all bone graft procedures. Despite best efforts, a large percentage of spine fusions (up to 35%) fail to form a solid bony arthrodesis. This is a significant clinical problem and has led to research in bone formation biology to augment spine fusion rates.
S T, Yoon, S D, Boden
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Current treatment and novel insights regarding ROS1‐targeted therapy in malignant tumors

Cancer Medicine
Background The proto‐oncogene ROS1 encodes an intrinsic type I membrane protein of the tyrosine kinase/insulin receptor family. ROS1 facilitates the progression of various malignancies via self‐mutations or rearrangements.
Shizhe Li, He Zhang, Ting Chen, Xiaowen Zhang, Guanning Shang   +4 more
doaj   +1 more source

Uncovering the Localization and Function of a Novel Read-Through Transcript ‘TOMM40-APOE’

Cells, 2023
Recent advancements in genome analysis technology have revealed the presence of read-through transcripts in which transcription continues by skipping the polyA signal. We here identified and characterized a new read-through transcript, TOMM40-APOE.
Shichen Chang, Satoru Torii, Jun Inamo, Kinya Ishikawa, Yuta Kochi, Shigeomi Shimizu   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source