Results 61 to 70 of about 3,986,989 (305)

Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia

Frontiers in Oncology, 2017
In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.
Valentina Tosato, Valentina Tosato, Valentina Tosato, Nicole West, Jan Zrimec, Dmitri V. Nikitin, Giannino Del Sal, Roberto Marano, Michael Breitenbach, Carlo V. Bruschi, Carlo V. Bruschi   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A mechanism of protein localization : the signal hypothesis and bacteria [PDF]

, 1980
We are studying the molecular mechanism of cellular protein localization. The availability of genetic techniques, such as gene fusion in Escherichia coli, has made this problem particularly amenable to study in this prokaryote.
Hall, M. N., Silhavy, T. J., Emr, S. D., T J Silhavy, S D Emr, M N Hall   +5 more
core   +1 more source

Pediatric Cutaneous Anaplastic Lymphoma Kinase-Positive Histiocytosis with DCTN1::ALK Fusion: A Case Report and Literature Search

Diagnostics
Background and Clinical Significance: Anaplastic lymphoma kinase (ALK)-positive histiocytosis is a relatively novel entity, affecting single or multiple organ systems; it is characterized by aggregates of neoplastic cells of the histiocytic lineage ...
Kristóf Levente Korpás, Attila Mokánszki, Lívia Beke, Gábor Méhes, Yi-Che Chang Chien   +4 more
doaj   +1 more source

Detecting and visualizing gene fusions

Methods, 2013
In recent years, gene fusions have gained significant recognition as biomarkers. They can assist treatment decisions, are seldom found in normal tissue and are detectable through Next-generation sequencing (NGS) of the transcriptome (RNA-seq). To transform the data provided by the sequencer into robust gene fusion detection several analysis steps are ...
Supper, Jochen, Gugenmus, Claudia, Wollnik, Johannes, Drueke, Tanja, Scherf, Matthias, Hahn, Alexander, Grote, Korbinian, Bretschneider, Nancy, Klocke, Bernward, Zinser, Christian, Cartharius, Kerstin, Seifert, Martin   +11 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Computational Mechanism Design for Information Fusion within Sensor Networks

, 2006
Conventional centralised information fusion and control architectures will be challenged by developments in sensor networks that allow sophisticated autonomous sensors, owned by different stakeholders with individual goals, to interact and share ...
S. Reece, N. Jennings, Dash, Rajdeep K, Rogers, Alex, Dash, RK, S. Roberts, Roberts, Stephen, Jennings, N. R., Roberts, S, Rogers, A, Reece, Steve, R. Dash, A. Rogers, Dash, Rajdeep K., Jennings, NR, Reece, S, IEEE   +16 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Studies on D-3^He Fusion in LHD [PDF]

, 1996
In LHD ( Large Helical Device ) studies on realization of D-D fusion burning has been carried out, where tritium burning is out of this plan. We propose experiments on D-^3He fusion in this plan. This fueled fusion has the reaction cross-section as large
YAMAZAKI, Kozo, FUJIWARA, Masami, IIYOSHI, Atsuo, SUDO, Shigeru, MURAKAMI, Sadayoshi, KANNO, Ryutaro, TOMITA, Yukihiro, OHYABU, Nobuyoshi, SASAO, Mamiko, OKAMOTO, Masao, KANEKO, Osamu, TAKEIRI, Yasuhiko, MUTOH, Takashi   +12 more
core  

A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia [PDF]

, 2010
Background: Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion genes have been cloned and ...
Meyer, Claus, Santos Joana, Claus Meyer, Lucília Norton, Susana Bizarro, Lisboa, Susana, Joana Santos, Cecília Correia, Lisboa Susana, Susana Lisboa, Meyer Claus, Teixeira Manuel R, Nuno Cerveira, Torres, Lurdes, Marschalek Rolf, Torres Lurdes, Norton Lucília, Correia, Cecilia, Pinheiro Manuela, Santos, Joana, Bizarro, Susana, Correia Cecília, Teixeira, Manuel R., Manuel R Teixeira, Pinheiro, Manuela, Cerveira Nuno, Marschalek, Rolf (Prof. Dr.), Rolf Marschalek, Lurdes Torres, Manuela Pinheiro, Cerveira, Nuno, Norton, Lucilia, Bizarro Susana   +32 more
core   +2 more sources