Results 51 to 60 of about 3,986,989 (305)
Orthopedic Clinics of North America, 2000 Gene therapy is a novel therapeutic modality for repair and regeneration of musculoskeletal tissues, including the spine. Various methods for therapeutic gene transfer are presented in this article. Several studies in which gene transfer has been used specifically to enhance spine fusion in animal models are reviewed.
Khan, Safdar N. +5 more
openaire +5 more sources
A Case of Melanoma Harboring an Anaplastic Lymphoma Kinase Gene Fusion
罕见病研究Anaplastic lymphoma kinase (ALK) gene fusions occur in a variety of tumors and have become important therapeutic targets for multiple cancer types. ALK inhibitors have demonstrated antitumor activity in various tumors with ALK gene fusion.
DU Yu, SI Lu
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Development of retroviral vectors for selective gene transfer into haematopoietic precursor cells and investigation of the gamma-retroviral R-peptide mediated membrane fusion [PDF]
, 2009 Eine in vivo Modifizierung von Blutstammzellen wäre für eine Reihe gentherapeutischer Therapieansätze vorteilhaft. Dies würde voraussetzen, dass retrovirale Vektoren gezielt auf Blutstammzellen ausgerichtet werden können.
Bobkova, Maria
core
Frontiers in OncologySS18::POU5F1-fused sarcoma is an exceedingly rare malignant tumor, with only isolated case reports documented to date. We present the first reported case of SS18::POU5F1 fusion sarcoma occurring in the left submandibular gland of a middle-aged male ...
Zhaorong Niu +7 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Design of Intense Neutron Source for Fusion Material Study and the Role of Universities [PDF]
, 1993 Need and requirement for the intense neutron source for fusion materials study have been discussed for many years. Recently, international climate has been becoming gradually maturing to consider this problem more seriously because of the recognition of ...
ISHINO, Shiori
core
CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
Cell Reports, 2021 Summary: Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that is driven primarily by a transcriptional coactivator fusion composed of cyclic AMP-regulated transcriptional coactivator 1 (CRTC1) and mastermind-like 2 (MAML2). The
Adele M. Musicant +16 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The fusion landscape of hepatocellular carcinoma
Molecular Oncology, 2019 Most cases of hepatocellular carcinoma (HCC) are already advanced at the time of diagnosis, which limits treatment options. Challenges in early‐stage diagnosis may be due to the genetic complexity of HCC.
Chengpei Zhu +11 more
doaj +1 more source