Results 31 to 40 of about 3,986,989 (305)

The rapidly changing field of predictive biomarkers of non-small cell lung cancer

Pathology and Oncology Research
Lung cancer is a leading cause of cancer-related death worldwide in both men and women, however mortality in the US and EU are recently declining in parallel with the gradual cut of smoking prevalence.
László József Tóth, Attila Mokánszki, Gábor Méhes   +2 more
doaj   +1 more source

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

Cell Genomics, 2022
Summary: Complex somatic genomic rearrangements and copy number alterations are hallmarks of nearly all cancers. We have developed an algorithm, LINX, to aid interpretation of structural variant and copy number data derived from short-read, whole-genome ...
Charles Shale, Daniel L. Cameron, Jonathan Baber, Marie Wong, Mark J. Cowley, Anthony T. Papenfuss, Edwin Cuppen, Peter Priestley   +7 more
doaj   +1 more source

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein [PDF]

, 2005
Tumors have evolved elaborate mechanisms for evading immune detection, such as production of immunoinhibitory cytokines and down-regulation of major histocompatibility complex (MHC) expression.
Hubank, M, Antigoni Papanastasiou, Nabarro, S, Sebire, N, Himoudi, N, Papanastasiou, A, Blundell, MP, Gibson, S, Gilmour, K, Anderson, J, Adrian Thrasher, Neil Sebire, John Anderson, Mike Hubank, Nourredine Himoudi, Kimberly Gilmour, Sian Gibson, Canderan, G, Stephen Nabarro, Glenda Canderan, Thrasher, A, Michael P. Blundell   +21 more
core   +1 more source

From genomic spectrum of NTRK genes to adverse effects of its inhibitors, a comprehensive genome-based and real-world pharmacovigilance analysis

Frontiers in Pharmacology
Introduction: The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions has facilitated the development of precision oncology. Two first-generation NTRK inhibitors (larotrectinib and entrectinib) are currently approved for the treatment ...
Zhiwei Cui, Zhen Zhai, De Xie, Lihui Wang, Feiyan Cheng, Siyu Lou, Fan Zou, Rumeng Pan, Shixue Chang, Haoyan Yao, Jing She, Yidan Zhang, Xinyuan Yang   +12 more
doaj   +1 more source

The impact of tandem duplication on gene evolution in Solanaceae species

Journal of Integrative Agriculture, 2022
Whole genome duplication (WGD) and tandem duplication (TD) are important modes of gene amplification and functional innovation, and they are common in plant genome evolution.
Yi-le HUANG, Ling-kui ZHANG, Kang ZHANG, Shu-min CHEN, Jian-bin HU, Feng CHENG   +5 more
doaj   +1 more source

Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

Neoplasia: An International Journal for Oncology Research, 2007
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG.
Kirsten D. Mertz, Sunita R. Setlur, Saravana M. Dhanasekaran, Francesca Demichelis, Sven Perner, Scott Tomlins, Joëlle Tchinda, Bharathi Laxman, Robert L. Vessella, Rameen Beroukhimt, Charles Lee, Arul M. Chinnaiyan, Mark A. Rubin   +12 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gene fusion and functional diversification of P450 genes facilitate thermophilic fungal adaptation to temperature change

Mycology
Thermomyces dupontii harbors two P450 paralogs (P450S and P450L) in the gene cluster for the biosynthesis of prenylated indole alkaloids (PIAs) and correponding iron chelators with P450L assigned as one protein containing a CYP like domain fused with a ...
Shuhong Li, Jiangbo He, Qunfu Wu, Jianghui Gou, Donglou Wang, Xuemei Niu   +5 more
doaj   +1 more source

SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review [PDF]

Middle East Journal of Cancer, 2020
Background: Synovial sarcoma is an aggressive soft tissue sarcoma. It has a wide spectrum of histopathologic patterns and uncertain immunohistochemistry, rendering it a diagnostic challenge.
Akbar Safaei, Elham Jansar, Ahmad Monabati, Maral Mokhtari, Mehdi Montazer   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source