Results 91 to 100 of about 1,003,870 (312)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Integrative View of the Diversity and Evolution of SWEET and SemiSWEET Sugar Transporters

Frontiers in Plant Science, 2017
Sugars Will Eventually be Exported Transporter (SWEET) and SemiSWEET are recently characterized families of sugar transporters in eukaryotes and prokaryotes, respectively. SemiSWEETs contain 3 transmembrane helices (TMHs), while SWEETs contain 7.
Baolei Jia, Baolei Jia, Xiao Feng Zhu, Zhong Ji Pu, Yu Xi Duan, Lu Jiang Hao, Jie Zhang, Li-Qing Chen, Che Ok Jeon, Yuan Hu Xuan   +9 more
doaj   +1 more source

Salivary Gland Carcinoma: Novel Targets to Overcome Treatment Resistance in Advanced Disease

Frontiers in Oncology, 2020
Salivary gland carcinomas (SGC) account for less than 5% of head and neck malignant neoplasms, further subcategorized in over 20 histological subtypes. For the most part, treatment for advanced disease is guided by morphology.
Larissa Di Villeneuve, Ive Lima Souza, Fernanda Davila Sampaio Tolentino, Renata Ferrarotto, Gustavo Schvartsman   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. [PDF]

, 2009
Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and ...
Berkel, W.J.H., van, Eulberg, D., Kaschabek, S.R., Lakner, S., Schloemann, M., Tischler, D.   +5 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Construction of plasmids containing IBDV VP2/4/3 and ChIL-18 fusion genes and co-expression genes as well as proteins expressed on Vero cells

浙江大学学报. 农业与生命科学版, 2010
In order to improve the immunity effect of infectious bursal disease virus (IBDV) polyprotein (VP2/4/3) DNA vaccine, fusion genes of IBDV polyprotein (VP2/4/3) gene and chicken interleukin 18 (ChIL-18) gene were constructed using the technique of ...
HOU Xian-hong, WEI Yong-wei, ZHANG Xiao-dong, YU Lian   +3 more
doaj   +1 more source

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Generation of Successive Unmarked Mutations and Chromosomal Insertion of Heterologous Genes in Actinobacillus pleuropneumoniae Using Natural Transformation [PDF]

, 2014
We have developed a simple method of generating scarless, unmarked mutations in Actinobacillus pleuropneumoniae by exploiting the ability of this bacterium to undergo natural transformation, and with no need to introduce plasmids encoding recombinases or
A Maas, A Maas, Alexander W. Tucker, Andrew N. Rycroft, B Zhan, Brendan W. Wren, C O'Neill, Denise M. Soares-Bazzolli, Duncan J. Maskell, EA Izano, FF Buettner, G Li, Glenn Francis Browning, H Maughan, I Jacobsen, I Jacobsen, Janine T. Bossé, JT Bossé, JT Bossé, JT Bossé, JT Bossé, JT Bossé, JT Bossé, L Lin, LM Mullen, M Copass, M Ramjeet, N Baltes, N Baltes, N Baltes, N Baltes, N Baltes, Paul R. Langford, PJ Blackall, R Jansen, RJ Redfield, RM Jones, RV Joshi, SJ Foote, T Ali, TJ Inzana, W Oswald, W Tonpitak, W Tonpitak, WW Fung, Yanwen Li, Z Xu   +46 more
core   +5 more sources