Results 201 to 210 of about 1,003,870 (312)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Oral Undifferentiated Pleomorphic Sarcoma: A Novel <i>SPECC1L::TERT</i> Gene Fusion and a Comprehensive Literature Review. [PDF]

Genes (Basel)
Della Mura M, Sorino J, Maiorano E, Cazzato G, Colagrande A, Manfuso A, Caporusso C, Copelli C, Cascardi E.   +8 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

G3BP1::CSF1R: a new and actionable gene fusion in acute megakaryoblastic leukemia. [PDF]

Blood Adv
Luo X, Cheng CK, Chan HY, Leung KT, Li CK, Chung NY, Pitts HA, Tian K, Kam YF, Ng MHL.   +9 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Characterization of a novel comprehensive genomic profiling test with better detection of heterozygous deletions and RNA-based gene fusion analysis. [PDF]

Oncologist
Kakuta R, Takemoto A, Tanimoto K, Noji R, Kudo R, Kano Y, Ando Y, Simoi T, Kinugasa Y, Ikeda S.   +9 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland Adenomas. [PDF]

Genes Chromosomes Cancer
Afshari MK, Tejera Nevado P, Fehr A, Huang J, Jäwert F, Nilsson JA, Stenman G, Andersson MK.   +7 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Rare case report: sclerosing epithelioid fibrosarcoma with FUS-CREB3L1 gene fusion. [PDF]

Front Oncol
Wang T, Xu H, Li C.
europepmc   +1 more source