Results 241 to 250 of about 3,986,989 (305)

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum. [PDF]

Genes Chromosomes Cancer
Saoud C, Gundem G, Domenico D, Arango-Ossa JE, Reed D, Vaynrub M, Papaemmanouil E, Bale TA, Linos K.   +8 more
europepmc   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

The Imaging Appearance of EWSR1::PATZ1 Gene Fusion Central Nervous System Tumors. [PDF]

J Belg Soc Radiol
Vanmarcke C, Marcelis L, Bempt IV, Sciot R, Devos J.   +4 more
europepmc   +1 more source

Self‐Assembled Hybrid Cell‐Enzyme Materials for Gas‐Powered Biocatalysis

Advanced Functional Materials, EarlyView.
Integrating living cells with programmable enzyme networks enables hybrid materials that convert gaseous feedstocks into chemical reducing power. These gas‐powered catalytic beads operate as modular, recyclable platforms for adaptive biocatalysis and sustainable synthesis.
Marius Stoeckle, Kersten S. Rabe, Christof M. Niemeyer   +2 more
wiley   +1 more source

Modulation of the <i>ETV6::RUNX1</i> Gene Fusion Prevalence in Newborns by Corticosteroid Use During Pregnancy. [PDF]

Int J Mol Sci
Benítez L, Fischer U, Crispi F, Castro-Barquero S, Crovetto F, Larroya M, Youssef L, Kameri E, Castillo H, Bueno C, Casas R, Borras R, Vieta E, Estruch R, Menéndez P, Borkhardt A, Gratacós E.   +16 more
europepmc   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity. [PDF]

Patterns (N Y)
Bian W, Zhang B, Song Z, Knisbacher BA, Chan YM, Bao C, Xu C, Wang W, Chu AHY, Lu C, Wang H, Bao S, Gong Z, Keung HY, Chow ZM, Zhang Y, Cheuk W, Getz G, Nardi V, Yang M, Cho WCS, Wang J, Chen J, Zheng Z.   +23 more
europepmc   +1 more source

Diffuse glioma with <i>FGFR3</i>::<i>TACC3</i> gene fusion and prominent calcification: A case report. [PDF]

Radiol Case Rep
Kusunoki M, Togao O, Yamashita K, Kikuchi K, Kuga D, Fujioka Y, Akamine S, Ishigami K.   +7 more
europepmc   +1 more source

Clinical and Pathological Features of a Schwannoma Harboring a SH3PXD2A::HTRA1 Gene Fusion in a Pre-pubescent Patient. [PDF]

Pediatr Dev Pathol
Glembocki A, Siddaway R, Arnoldo A, Jakeman M, Lafreniere A.   +4 more
europepmc   +1 more source