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2021
Fusion gene is a hybrid form of two distinct genes resulting in broad spectrum of downstream pathway alterations. Gene fusion events are mostly from genomic rearrangements though diverse mechanisms have now been identified from in-depth analyses of next generation sequencing data.
Jisun, Kim, Wonshik, Han
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Fusion gene is a hybrid form of two distinct genes resulting in broad spectrum of downstream pathway alterations. Gene fusion events are mostly from genomic rearrangements though diverse mechanisms have now been identified from in-depth analyses of next generation sequencing data.
Jisun, Kim, Wonshik, Han
openaire +2 more sources
Gene Fusions in Thyroid Cancer
Thyroid, 2018Gene fusions are known in many cancers as driver or passenger mutations. They play an important role in both the etiology and pathogenesis of cancer and are considered as potential diagnostic and prognostic markers and possible therapeutic targets.
Valentina D, Yakushina +2 more
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Irradiation and Fusion Gene Transfer
2003The fusion of human and rodent somatic cells is usually followed by the spontaneous loss of human chromosomes from the hybrid cells (1). The correlation between the presence of a human chromosome retained in the hybrid cell and the presence of a human phenotypic trait is the basis of human gene mapping by somatic cell genetics (2).
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Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution
Genes, 2021Hideki Innan, Cian Glenfield
exaly