Results 11 to 20 of about 7,252,476 (351)
Computational and Structural Biotechnology Journal, 2021 Transcript isoforms regulated by alternative splicing can substantially impact carcinogenesis, leading to a need to obtain clues for both gene differential expression and malfunctions of isoform distributions in cancer studies.
Tzu-Hsien Yang +8 more
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medRxiv, 2023 Genomic regulatory elements active in the developing human brain are notably enriched in genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia, and bipolar disorder.
C. Wen +36 more
semanticscholar +1 more source
TAGET: a toolkit for analyzing full-length transcripts from long-read sequencing
Nature Communications, 2023 Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by PacBio can generate very long and accurate reads, thus providing an ideal platform for full-length transcriptome analysis.
Yuchao Xia +10 more
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Isoform-specific functions of PPARγ in gene regulation and metabolism
Genes & Development, 2022 In this study, Hu et al. investigated the specific functions of the two main PPARγ isoforms by generating mouse lines in which endogenous PPARγ1 and PPARγ2 were epitope-tagged to interrogate isoform-specific genomic binding, and mice deficient in either ...
Wenxiang Hu +11 more
semanticscholar +1 more source
High-throughput RNA isoform sequencing using programmed cDNA concatenation
Nature Biotechnology, 2023 Full-length RNA-sequencing methods using long-read technologies can capture complete transcript isoforms, but their throughput is limited. We introduce multiplexed arrays isoform sequencing (MAS-ISO-seq), a technique for programmably concatenating ...
Aziz M Al'Khafaji +18 more
semanticscholar +1 more source
Frontiers in Genetics, 2021 The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to cancer ...
Carlos Farkas +9 more
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A large-scale comparative study of isoform expressions measured on four platforms
BMC Genomics, 2020 Background Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is necessary to accurately measure isoform ...
Wei Zhang +6 more
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Improved prediction of smoking status via isoform-aware RNA-seq deep learning models.
PLoS Computational Biology, 2021 Most predictive models based on gene expression data do not leverage information related to gene splicing, despite the fact that splicing is a fundamental feature of eukaryotic gene expression.
Zifeng Wang +11 more
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Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue
Nature Biotechnology, 2022 Single-nuclei RNA sequencing characterizes cell types at the gene level. However, compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack barcodes and hinder the study of isoforms.
S. Hardwick +29 more
semanticscholar +1 more source
Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer [PDF]
PeerJ, 2022 Background Breast cancer is the second leading cause of cancer-related deaths globally, and its prevalence rates are increasing daily. In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption that one gene is ...
Mehar Masood +5 more
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