Results 11 to 20 of about 470,447 (304)
Novel Chicken Actin Gene: Third Cytoplasmic Isoform [PDF]
Molecular and Cellular Biology, 1985 We identified a novel chicken actin gene. The actin protein deduced from its nucleotide sequence very closely resembles the vertebrate cytoplasmic actins; accordingly, we classified this gene as a nonmuscle type. We adopted the convention for indicating the nonmuscle actins of the class Amphibia (Vandekerckhove et al., J. Mol. Biol.
D J, Bergsma, K S, Chang, R J, Schwartz
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Frontiers in Genetics, 2021 The SALL2 transcription factor, an evolutionarily conserved gene through vertebrates, is involved in normal development and neuronal differentiation. In disease, SALL2 is associated with eye, kidney, and brain disorders, but mainly is related to cancer ...
Carlos Farkas +9 more
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A large-scale comparative study of isoform expressions measured on four platforms
BMC Genomics, 2020 Background Most eukaryotic genes produce different transcripts of multiple isoforms by inclusion or exclusion of particular exons. The isoforms of a gene often play diverse functional roles, and thus it is necessary to accurately measure isoform ...
Wei Zhang +6 more
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Improved prediction of smoking status via isoform-aware RNA-seq deep learning models.
PLoS Computational Biology, 2021 Most predictive models based on gene expression data do not leverage information related to gene splicing, despite the fact that splicing is a fundamental feature of eukaryotic gene expression.
Zifeng Wang +11 more
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APPRIS 2017: principal isoforms for multiple gene sets [PDF]
Nucleic Acids Research, 2017 The APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single protein isoform, the 'principal' isoform, as the reference for each gene based on these annotations.
Rodriguez, Jose M. +5 more
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Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer [PDF]
PeerJ, 2022 Background Breast cancer is the second leading cause of cancer-related deaths globally, and its prevalence rates are increasing daily. In the past, studies predicting therapeutic drug targets for cancer therapy focused on the assumption that one gene is ...
Mehar Masood +5 more
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Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis. [PDF]
PLoS ONE, 2015 Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 ...
Cheng Zhan +7 more
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F1000Research, 2019 Next generation sequencing protocols such as RNA-seq have made the genome-wide characterization of the transcriptome a crucial part of many research projects in biology.
Christophe D. Chabbert +4 more
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Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. [PDF]
, 2014 Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a ...
Bi, Yingtao +5 more
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Differential Regulation of Gene Expression by PITX2 Isoforms [PDF]
Journal of Biological Chemistry, 2002 Three major PITX2 isoforms are differentially expressed in human, mice, zebrafish, chick, and frog tissues. To demonstrate differential regulation of gene expression by these isoforms we used three different promoters and three cell lines. Transient transfection of Chinese hamster ovary, HeLa, and LS-8 cell lines revealed differences in PITX2A and ...
Carol J, Cox +7 more
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