Results 11 to 20 of about 6,900,738 (371)
The Actin Gene Family: Function Follows Isoform [PDF]
Cytoskeleton, 2010 Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence ...
B. Perrin, J. Ervasti
semanticscholar +4 more sources
A novel isoform of the Ly108 gene ameliorates murine lupus [PDF]
Journal of Experimental Medicine, 2011 The expression of the new Ly108 isoform H1 weakens lupus-like disease of C57BL/6.Sle1b mice.
Marton Keszei +18 more
semanticscholar +6 more sources
Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds* [PDF]
Journal of Biological Chemistry, 2012 Background: The functional significance of hemoglobin heterogeneity remains a mystery. Results: In adult birds, the HbD isoform (related to embryonic hemoglobin) exhibits distinct oxygenation properties relative to the major HbA isoform.
M. Grispo +5 more
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Gene Expreession and Function of Progesterone Receptor Isoforms
Folia Endocrinologica Japonica, 1994 Progesterone receptor is unique in terms of the existence of two isoforms of A and B. The isoforms are expressed by two distinct promoters in the peripheral as well as the brain. The 5'-untranslated region and the coding region around ATG 1 of rat progesterone receptor form B as well as the ligand binding domain are cloned.
Junzo Kato
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Isoform-Specific Imprinting of the Human PEG1/MEST Gene [PDF]
The American Journal of Human Genetics, 2000 We thank Mr. Taichi Suzuki, from Tokyo Technical College, for excellent laboratory assistance. This work was supported, in part, by a grant from the Pharmacia-Upjohn Fund for Growth & Development Research.
Kenjiro Kosaki +3 more
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Biochemical and Biophysical Research Communications, 2000 The CDK10/PISSLRE gene has been shown to encode two different CDK-like putative kinases. The function(s) of the gene products are unknown, although a role at the G2/M transition has been suggested. We characterised two novel cDNAs. CDK10 mRNA quantity was not found to be correlated with cell proliferation status in HeLa or WI38 cell cultures or in ...
Jean‐Christophe Sergère +4 more
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Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues [PDF]
Science, 2012 Whence Species Variation? Vertebrates have widely varying phenotypes that are at odds with their much more limited proteincoding genotypes and conserved messenger RNA expression patterns. Genes with multiple exons and introns can undergo alternative splicing, potentially resulting in multiple protein isoforms (see the Perspective
J. Merkin +3 more
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The spatial landscape of gene expression isoforms in tissue sections [PDF]
Nucleic Acids Research, 2020 Abstract In situ capturing technologies add tissue context to gene expression data, with the potential of providing a greater understanding of complex biological systems. However, splicing variants and full-length sequence heterogeneity cannot be characterized at spatial resolution with current transcriptome profiling methods.
Kevin Lebrigand +7 more
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Characterization of Rubisco Activase Genes in Maize: An α-Isoform Gene Functions alongside a β-Isoform Gene [PDF]
Plant Physiology, 2014 Rubisco activase (RCA) catalyzes the activation of Rubisco in vivo and plays a crucial role in regulating plant growth. In maize (Zea mays), only β-form RCA genes have been cloned and characterized. In this study, a genome-wide survey revealed the presence of an α-form RCA gene and a β-form RCA gene in the maize genome, herein referred to as ZmRCAα and
Zhitong Yin +9 more
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The ZFHX1A gene is differentially autoregulated by its isoforms [PDF]
Biochemical and Biophysical Research Communications, 2007 The Zfhx1a gene expresses two different isoforms; the full length Zfhx1a-1 and a truncated isoform termed Zfhx1a-2 lacking the first exon. Deletion analysis of the Zfhx1a-1 promoter localized cell-specific repressors, and a proximal G-string that is critically required for transactivation.
Manavella, Pablo Andrés +3 more
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