Results 11 to 20 of about 413,820 (357)
Gene Expreession and Function of Progesterone Receptor Isoforms
Folia Endocrinologica Japonica, 1994 Progesterone receptor is unique in terms of the existence of two isoforms of A and B. The isoforms are expressed by two distinct promoters in the peripheral as well as the brain. The 5'-untranslated region and the coding region around ATG 1 of rat progesterone receptor form B as well as the ligand binding domain are cloned.
Junzo Kato
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Isoform-Specific Imprinting of the Human PEG1/MEST Gene [PDF]
The American Journal of Human Genetics, 2000 We thank Mr. Taichi Suzuki, from Tokyo Technical College, for excellent laboratory assistance. This work was supported, in part, by a grant from the Pharmacia-Upjohn Fund for Growth & Development Research.
Kenjiro Kosaki +3 more
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Biochemical and Biophysical Research Communications, 2000 The CDK10/PISSLRE gene has been shown to encode two different CDK-like putative kinases. The function(s) of the gene products are unknown, although a role at the G2/M transition has been suggested. We characterised two novel cDNAs. CDK10 mRNA quantity was not found to be correlated with cell proliferation status in HeLa or WI38 cell cultures or in ...
Jean‐Christophe Sergère +4 more
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The spatial landscape of gene expression isoforms in tissue sections [PDF]
Nucleic Acids Research, 2020 Abstract In situ capturing technologies add tissue context to gene expression data, with the potential of providing a greater understanding of complex biological systems. However, splicing variants and full-length sequence heterogeneity cannot be characterized at spatial resolution with current transcriptome profiling methods.
Kevin Lebrigand +7 more
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Characterization of Rubisco Activase Genes in Maize: An α-Isoform Gene Functions alongside a β-Isoform Gene [PDF]
Plant Physiology, 2014 Rubisco activase (RCA) catalyzes the activation of Rubisco in vivo and plays a crucial role in regulating plant growth. In maize (Zea mays), only β-form RCA genes have been cloned and characterized. In this study, a genome-wide survey revealed the presence of an α-form RCA gene and a β-form RCA gene in the maize genome, herein referred to as ZmRCAα and
Zhitong Yin +9 more
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The ZFHX1A gene is differentially autoregulated by its isoforms [PDF]
Biochemical and Biophysical Research Communications, 2007 The Zfhx1a gene expresses two different isoforms; the full length Zfhx1a-1 and a truncated isoform termed Zfhx1a-2 lacking the first exon. Deletion analysis of the Zfhx1a-1 promoter localized cell-specific repressors, and a proximal G-string that is critically required for transactivation.
Manavella, Pablo Andrés +3 more
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The FU gene and its possible protein isoforms [PDF]
BMC Genomics, 2004 Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci). Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors.
Charles E. Schwartz +9 more
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The actin gene family: Function follows isoform [PDF]
Cytoskeleton, 2010 AbstractAlthough actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence.
James M. Ervasti, Benjamin J. Perrin
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A novel isoform of the Ly108 gene ameliorates murine lupus [PDF]
Journal of Experimental Medicine, 2011 Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease.
Keszei, Marton +18 more
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Isoform function prediction by Gene Ontology embedding
Bioinformatics, 2022 AbstractMotivationHigh-resolution annotation of gene functions is a central task in functional genomics. Multiple proteoforms translated from alternatively spliced isoforms from a single gene are actual function performers and greatly increase the functional diversity.
Sichao Qiu +4 more
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