Results 251 to 260 of about 6,900,738 (371)

Super-enhancer-mediated circRNAs exhibit high splicing circularization diversity and transcriptional activity. [PDF]

Nucleic Acids Res
Huang S, Han Y, Liu Y, Bu L, Wu C, Rao Z, Ye C, Cheng H, Liao Y, Sun Y, Zou Y, Wang Z, Sun BY, Meng S, Zhao D.   +14 more
europepmc   +1 more source

The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing

, 2000
Karine Hovanes, Tony W.H. Li, Marian L. Waterman   +2 more
openalex   +1 more source

Differential control of gene activity by isoforms A, B1 and B2 of the Drosophila ecdysone receptor [PDF]

, 2001
Jean‐François Mouillet, Vincent C. Henrich, Markus Lezzi, Martin Vögtli   +3 more
openalex   +1 more source

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

TRs Have Common and Isoform-Specific Functions in Regulation of the Cardiac Myosin Heavy Chain Genes [PDF]

, 2001
Anethe Mansén, Fushun Yu, Douglas Forrest, Lars Larsson, Björn Vennström   +4 more
openalex   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Isoform-Specific Mutations in the Caenorhabditis elegans Heterochronic Gene lin-14 Affect Stage-Specific Patterning [PDF]

, 2001
Brenda J. Reinhart, Gary Ruvkun
openalex   +1 more source

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Molecular and Cellular Biology, 2000
Steffen Jung, J. Aliberti, Petra Graemmel, M. Sunshine, G. Kreutzberg, A. Sher, D. Littman   +6 more
semanticscholar   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Using computer-generated protein models to analyze mutations linked to Amelogenesis Imperfecta. [PDF]

PLoS One
Sharmin N, Yuan J, Chow AK.
europepmc   +1 more source