Results 251 to 260 of about 7,252,476 (351)

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. [PDF]

Circulation
Pan T, Lu L, Youker K, Shiau CK, Wang M, Lin HY, Nguyen A, He Y, Tong E, Zhu P, Ranka R, Yan Y, Sinha A, Bharat A, Eagar T, Wilcox J, Bhimaraj A, Gao R.   +17 more
europepmc   +1 more source

Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence [PDF]

Jack B. Roberts, Olivia Lucy Georgina Boldvig, Guillaume Aubourg, Sai Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin   +6 more
openalex   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response. [PDF]

Genome Biol
Devaux A, Tanaka I, Fouilleul Q, Heneman-Masurel A, Cadix M, Michallet S, Chakraborty A, Labbé CM, Fontrodona N, Sahoo S, Claude JB, Deloger M, Gestraud P, Tessier L, Mortada H, Lameiras S, Raynal V, Baulande S, Servant N, Auboeuf D, Eymin B, Vagner S, Dutertre M.   +22 more
europepmc   +1 more source

Alterations in mRNA 3′UTR Isoform Abundance Accompany Gene Expression Changes in Huntington's Disease

, 2017
Lindsay Romo
openalex   +1 more source

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation [PDF]

, 2013
Jennifer Munkley, Prabhakar Rajan, Nicholas P. Lafferty, Caroline Dalgliesh, Robert M. Jackson, Craig Robson, Hing Y. Leung, David J. Elliott   +7 more
openalex   +1 more source

SV2B Promotes the Progression of TFE3‐Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF‐κB Subunits

Advanced Science, EarlyView.
TFE3‐rearranged renal cell carcinoma (TFE3‐RCC) lacks clearly defined diagnostic and therapeutic targets. SV2B, a TFE3 target gene, promotes TFE3‐RCC progression by activating the NF‐κB pathway. Targeted inhibition with padsevonil or Withaferin A effectively suppresses tumor progression.
Huayi Feng, Zhuang Xiong, Shaoqing Yu, Junxiao Liu, Shouqing Cao, Kan Liu, Xing Huang, Lequan Wen, Baojun Wang, Qingbo Huang, Tiejun Pan, Xu Zhang, Xin Ma, Xiubin Li   +13 more
wiley   +1 more source

Vitamin D elicits tissue-specific isoform expression in Atlantic salmon muscles. [PDF]

BMC Genomics
Gorman CE, McGinnity P, Hulsey CD.
europepmc   +1 more source

Gene regulatory network rewiring by disease variants and transcription factor isoforms

, 2018
Juan Fuxman Bass
openalex   +1 more source