Results 251 to 260 of about 470,447 (304)

Maintaining sexual identity in adult flies is an ongoing commitment. [PDF]

PLoS Biol
Kopp A.
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response. [PDF]

Genome Biol
Devaux A, Tanaka I, Fouilleul Q, Heneman-Masurel A, Cadix M, Michallet S, Chakraborty A, Labbé CM, Fontrodona N, Sahoo S, Claude JB, Deloger M, Gestraud P, Tessier L, Mortada H, Lameiras S, Raynal V, Baulande S, Servant N, Auboeuf D, Eymin B, Vagner S, Dutertre M.   +22 more
europepmc   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

Bioinformatics frameworks for single-cell long-read sequencing: unlocking isoform-level resolution. [PDF]

Brief Bioinform
Bhatia S, Field MA, Hebbard L, Schmitz U.   +3 more
europepmc   +1 more source

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Vitamin D elicits tissue-specific isoform expression in Atlantic salmon muscles. [PDF]

BMC Genomics
Gorman CE, McGinnity P, Hulsey CD.
europepmc   +1 more source

ScIsoX: a multidimensional framework for measuring isoform-level transcriptomic complexity in single cells. [PDF]

Genome Biol
Wu S, Schmitz U.
europepmc   +1 more source

PSQAN: a pipeline to prioritize novel and biologically relevant transcripts from long-read RNA sequencing. [PDF]

Bioinform Adv
Sethi S, Gustavsson EK, Saini H, Ryten M.   +3 more
europepmc   +1 more source

Integrative and accurate annotations enhance current nonsense-mediated mRNA decay rules. [PDF]

Nucleic Acids Res
Iha H, Kikutake C, Suyama M.
europepmc   +1 more source