Results 21 to 30 of about 470,447 (304)
Global isoform-specific transcript alterations and deregulated networks in clear cell renal cell carcinoma. [PDF]
, 2018 Extensive genome-wide analyses of deregulated gene expression have now been performed for many types of cancer. However, most studies have focused on deregulation at the gene-level, which may overlook the alterations of specific transcripts for a given ...
Girke, Thomas +2 more
core +1 more source
The evolutionarily conserved avianAiolos gene encodes alternative isoforms [PDF]
European Journal of Immunology, 1999 Aiolos is an Ikaros-related lymphoid regulatory protein involved in B cell development and function. To evaluate the role of Aiolos in avian B lymphopoiesis, we have cloned and characterized the first non-mammalian Aiolos ortholog in the avian. In sharp contrast to the avian Ikaros, expressed already at the multipotential stage and prior to the ...
J, Liippo, A, Mansikka, O, Lassila
openaire +2 more sources
A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]
, 2016 The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.
Babicky, M +10 more
core +2 more sources
The FU gene and its possible protein isoforms [PDF]
BMC Genomics, 2004 Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci). Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors.
Østerlund, Torben +7 more
openaire +4 more sources
The p52 isoform of SHC1 is a key driver of breast cancer initiation
Breast Cancer Research, 2019 Background SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer.
Kevin D. Wright +11 more
doaj +1 more source
Nature Communications, 2021 H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X ...
Esther Griesbach +3 more
doaj +1 more source
A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]
, 2017 Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho +5 more
core +3 more sources
PLoS Computational Biology, 2013 Integrating large-scale functional genomic data has significantly accelerated our understanding of gene functions. However, no algorithm has been developed to differentiate functions for isoforms of the same gene using high-throughput genomic data.
Ridvan Eksi +6 more
doaj +1 more source
Obstacles to detecting isoforms using full-length scRNA-seq data
Genome Biology, 2020 Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples.
Jennifer Westoby +3 more
doaj +1 more source
The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
Cancer Cell International, 2021 Background Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a gene residing
Simon Keane +3 more
doaj +1 more source