Results 21 to 30 of about 413,820 (357)
Differential Regulation of Gene Expression by PITX2 Isoforms [PDF]
Journal of Biological Chemistry, 2002 Three major PITX2 isoforms are differentially expressed in human, mice, zebrafish, chick, and frog tissues. To demonstrate differential regulation of gene expression by these isoforms we used three different promoters and three cell lines. Transient transfection of Chinese hamster ovary, HeLa, and LS-8 cell lines revealed differences in PITX2A and ...
Brad A. Amendt +7 more
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Isoform switch of pyruvate kinase M1 indeed occurs but not to pyruvate kinase M2 in human tumorigenesis. [PDF]
PLoS ONE, 2015 Muscle type of pyruvate kinase (PKM) is one of the key mediators of the Warburg effect and tumor metabolism. Due to alternative splicing, there are at least 12 known isoforms of the PKM gene, of which PKM1 and PKM2 are two major isoforms with only a 23 ...
Cheng Zhan +7 more
doaj +1 more source
APPRIS 2017: principal isoforms for multiple gene sets [PDF]
Nucleic Acids Research, 2017 The APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single protein isoform, the 'principal' isoform, as the reference for each gene based on these annotations.
Rodriguez, Jose M. +5 more
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Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium. [PDF]
PLoS Genetics, 2013 CTP synthase is an essential enzyme that plays a key role in energy metabolism. Several independent studies have demonstrated that CTP synthase can form an evolutionarily conserved subcellular structure termed cytoophidium.
Ghows Azzam, Ji-Long Liu
doaj +1 more source
F1000Research, 2019 Next generation sequencing protocols such as RNA-seq have made the genome-wide characterization of the transcriptome a crucial part of many research projects in biology.
Christophe D. Chabbert +4 more
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Nature Communications, 2021 H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X ...
Esther Griesbach +3 more
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Discovery of two new isoforms of the human DUT gene
Scientific Reports, 2023 AbstractIn human cells two dUTPase isoforms have been described: one nuclear (DUT-N) and one mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two additional isoforms; DUT-3 without any localization signal and DUT-4 with the same nuclear localization signal as DUT-N.
Gergely Attila Rácz +5 more
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The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
Cancer Cell International, 2021 Background Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a gene residing
Simon Keane +3 more
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Gene Duplication and the Evolution of Hemoglobin Isoform Differentiation in Birds [PDF]
Journal of Biological Chemistry, 2012 The majority of bird species co-express two functionally distinct hemoglobin (Hb) isoforms in definitive erythrocytes as follows: HbA (the major adult Hb isoform, with α-chain subunits encoded by the α(A)-globin gene) and HbD (the minor adult Hb isoform, with α-chain subunits encoded by the α(D)-globin gene).
Grispo, Michael T +5 more
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The p52 isoform of SHC1 is a key driver of breast cancer initiation
Breast Cancer Research, 2019 Background SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer.
Kevin D. Wright +11 more
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