Results 21 to 30 of about 282,788 (245)

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

PLoS ONE, 2015
Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome.
Sarah Leigh-Brown, Angela Goncalves, David Thybert, Klara Stefflova, Stephen Watt, Paul Flicek, Alvis Brazma, John C Marioni, Duncan T Odom   +8 more
doaj   +1 more source

Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.

PLoS ONE, 2012
CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC.
Mari H Tervaniemi, H Annika Siitonen, Cilla Söderhäll, Gurinder Minhas, Jyrki Vuola, Inkeri Tiala, Raija Sormunen, Lena Samuelsson, Sari Suomela, Juha Kere, Outi Elomaa   +10 more
doaj   +1 more source

Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway

Computational and Structural Biotechnology Journal, 2022
The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun, Lu Li, Jiameng Hu, Yan Gao, Jinyi Song, Xiang Zhang, Haiyang Hu   +6 more
doaj   +1 more source

Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium.

PLoS Genetics, 2013
CTP synthase is an essential enzyme that plays a key role in energy metabolism. Several independent studies have demonstrated that CTP synthase can form an evolutionarily conserved subcellular structure termed cytoophidium.
Ghows Azzam, Ji-Long Liu
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Evolution of oleosin in land plants. [PDF]

PLoS ONE, 2014
Oleosins form a steric barrier surface on lipid droplets in cytoplasm, preventing them from contacting and coalescing with adjacent droplets. Oleosin genes have been detected in numerous plant species.
Yuan Fang, Rui-Liang Zhu, Brent D Mishler   +2 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Integrative gene and isoform co-expression networks reveal regulatory rewiring in stress-related psychiatric disorders

iScience
Summary: Isoform-specific expression patterns have been linked to stress-related psychiatric disorders such as major depressive disorder (MDD). To further explore their involvement, we constructed co-expression networks using total gene expression (TE ...
Ghalia Rehawi, Jonas Hagenberg, Philipp G. Sämann, Lambert Moyon, Elisabeth Binder, Markus List, Annalisa Marsico, Janine Knauer-Arloth   +7 more
doaj   +1 more source

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

Genome Biology, 2021
Introduction Genes contain multiple promoters that can drive the expression of various transcript isoforms. Although transcript isoforms from the same gene could have diverse and non-overlapping functions, current loss-of-function methodologies are not ...
Rebecca Davies, Ling Liu, Sheng Taotao, Natasha Tuano, Richa Chaturvedi, Kie Kyon Huang, Catherine Itman, Amit Mandoli, Aditi Qamra, Changyuan Hu, David Powell, Roger J. Daly, Patrick Tan, Joseph Rosenbluh   +13 more
doaj   +1 more source