Results 331 to 340 of about 6,900,738 (371)

The FindMNDBiomarker Program: Protein Changes in Motor Neuron Disease/Amyotrophic Lateral Sclerosis Postmortem Tissue and Biofluids

Annals of Neurology, EarlyView.
Objective Biomarkers of disease pathogenesis are critically needed for amyotrophic lateral sclerosis (ALS) to facilitate diagnosis and patient stratification into appropriate therapeutic trials. Proteomic studies offer significant potential to advance this, but reproducibility across laboratories is a key component toward identifying protein changes ...
Gabrielle L. Adler, Matthew C. Kiernan, Rachel H. Tan   +2 more
wiley   +1 more source

Correction: Isoform-specific disruption of the <i>TP73</i> gene reveals a critical role for TAp73γ in tumorigenesis via leptin.

Elife
Kong X, Yan W, Sun W, Zhang Y, Yang HJ, Chen M, Chen H, de Vere White RW, Zhang J, Chen X.   +9 more
europepmc   +1 more source

Retroelement co-option disrupts the cancer transcriptional programme. [PDF]

Genome Med
Loong J, Thompson R, Hall C, Doglio L, Pape J, Plowman T, Kassiotis G.   +6 more
europepmc   +1 more source

Extracellular Vesicles in Calcium Oxalate Nephrolithiasis: Emerging Biomarkers and Therapeutic Potential

Advanced NanoBiomed Research, EarlyView.
Kidney stones cause significant pain and healthcare costs. Current prediction, diagnosis, and treatment options are limited. Extracellular vesicles (EVs), rich in proteins, lipids, and nucleic acids, offer a promising solution. This review explores the roles of EVs in kidney stone management, highlighting their potential as biomarkers and therapeutic ...
Wang Zhu, Xu Changzhi, Deng Qiong, Liang Hui   +3 more
wiley   +1 more source

Rotifers in space: transcriptomic response of the bdelloid rotifer Adineta vaga aboard the International Space Station. [PDF]

BMC Biol
Moris VC, Bruneau L, Berthe J, Coos R, Baselet B, Heuskin AC, Caplin N, Demets R, Krause J, Zuijderduijn L, Tortora A, Herova M, Penninckx S, Parmitano L, Tabury K, Baatout S, Van Doninck K, Hespeels B.   +17 more
europepmc   +1 more source

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression. [PDF]

Commun Biol
Luo X, Xie L, Ma X, Chen N, Xu J, Jiang X, Liu X, Yang Y, Liu T, Yi P, Xu J.   +10 more
europepmc   +1 more source

Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α— Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation

Angewandte Chemie, EarlyView.
Visible‐light photoswitchable peptides enable the stabilization of the hydroxylated hypoxia transcription factor 1α (HIF1α—OH) by targeting the pVHL‐EloBC interaction. Significant differences in conformation, binding, and transcription of HIF‐targeted genes between the photostationary states (PSS) were demonstrated.
Van Tuan Trinh, Sabrina Fischer, Lei Zhang, Heiko Geisler, Belen Pardo, Robert Liefke, Frank Abendroth, Olalla Vázquez   +7 more
wiley   +1 more source

RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma. [PDF]

Elife
Huang J, Jia R, Guo J.
europepmc   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

Angewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li, Hong-Rui Zhang, Yang Yang, Ben Chi-Bun Ko, Jin Shang, Haijun Guo, Dan Yang, Mankin Wong, Ricky Wing-Cheung Chan, Karen Ka-Yan Kung, Qian Zhao   +10 more
wiley   +1 more source