Results 351 to 360 of about 6,900,738 (371)
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Characterization of a novel isoform of the human ORMDL3 gene
Cell and Tissue Research, 2011The locus on chromosome 17q21, that encompasses the orosomucoid 1-like protein 3 (ORMDL3) gene, was considered a susceptibility locus associated to asthma, ulcerative colitis and ankylosing spondylitis, and polymorphisms within this locus were thought to be associated to an increased expression of the ORMDL3 gene. Several phosphorylation sites in the N-
Rui Jin +5 more
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Profiling human phosphodiesterase genes and splice isoforms
Biochemical and Biophysical Research Communications, 2006A mere 21 human phosphodiesterase (PDE) genes are responsible for modulating cellular levels of cAMP and cGMP in response to stimuli. Considering the importance of cAMP and cGMP to disparate physiological functions including visual response, smooth muscle relaxation, platelet aggregation, immune response, and cardiac contractibility, perhaps the 200 or
Subhashini Srinivasan +2 more
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From “Junk” to Gene: Curriculum vitae of a Primate Receptor Isoform Gene
Journal of Molecular Biology, 2004Exonization of Alu retroposons awakens public opinion, particularly when causing genetic diseases. However, often neglected, alternative "Alu-exons" also carry the potential to greatly enhance genetic diversity by increasing the transcriptome of primates chiefly via alternative splicing.Here, we report a 5' exon generated from one of the two ...
Thomas Hehlgans +4 more
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The Rat H3 Receptor: Gene Organization and Multiple Isoforms
Biochemical and Biophysical Research Communications, 2001Genomic DNA analysis revealed that the coding region of the rat histamine H3 receptor comprises three exons interrupted by two introns of approximately 1 kb each. Several H3 receptor mRNA variants were identified by PCR and cDNA cloning and sequencing.
Morisset, Séverine +7 more
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Parallel gene size and isoform expansion of ancient neuronal genes
Current BiologyHow nervous systems evolved is a central question in biology. A diversity of synaptic proteins is thought to play a central role in the formation of specific synapses leading to nervous system complexity. The largest animal genes, often spanning hundreds of thousands of base pairs, are known to be enriched for expression in neurons at synapses and are ...
Matthew J. McCoy, Andrew Z. Fire
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Characterization of the murine Inpp4b gene and identification of a novel isoform
Gene, 2006Inositol polyphosphate phosphatases and phosphoinositides second messengers have been associated with major cellular functions as growth, differentiation, apoptosis, protein trafficking and motility. To characterize the role of inositol phosphatases in cell physiology, we have isolated the mouse Inositol polyphosphate 4-phosphatase type II (Inpp4b ...
Mathieu Ferron, Jean Vacher
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Localization of the gene encoding a novel isoform of lysyl hydroxylase
Mammalian Genome, 1997Journal Article ; Research Support, Non-U.S.
Szpirer, Claude +5 more
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Gene duplication and hemoglobin isoform differentiation
2018Chapter 6 explores the physiological significance of gene duplication and hemoglobin isoform differentiation. Repeated rounds of gene duplication and divergence during the evolution of jawed vertebrates promoted the diversification of the subfamilies of genes that encode the different subunit chains of tetrameric hemoglobin, leading to functional ...
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Gene Expression of Progesterone Receptor Isoforms in the Rat Brain
Hormones and Behavior, 1994Progesterone receptors (PRs) are known to exist in two forms: a larger molecular, form B, and a smaller one, form A. Rat PR cDNA corresponding to the region around the translation-initiation site (ATGB) of the putative PR form B mRNA was cloned, together with cloning of steroid-binding domain of the PR forms A and B.
Shuji Hirata +3 more
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Gene expression profiles of heme oxygenase isoforms in the rat brain
Brain Research, 2002In the last decade the heme oxygenase (HO) system has been strongly highlighted for its potential significance in maintaining cellular homeostasis. Nevertheless the physiological relevance of the three isoforms cloned to date, HO-1, HO-2 and HO-3, and their reciprocal interrelation have been poorly understood.
Vittorio Calabrese +7 more
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