Results 361 to 370 of about 6,900,738 (371)

Adenovirus-mediated gene transfer of SERCA isoforms

2000
Cultured chicken embryonic or neonatal rat cardiac myocytes were infected with recombinant adenovirus vectors carrying slow muscle SERCA2a or fast muscle SERCAla cDNA, under control of muscle-specific or constitutive viral promoters. Under optimal conditions, exogenous SERCA expression was obtained in all myocytes in culture, yielding approximately a ...
Carlota Sumbilla, J. M. O’donnell, Marco Cavagna, Giuseppe Inesi, Michael G. Klein, Hailun Ma, Lilin Zhong   +6 more
openaire   +2 more sources

Gene Transfer of Troponin I Isoforms, Mutants, and Chimeras

2003
Thin filament proteins play an essential role in the regulation of myocardial pressure development. Within the thin filament of the sarcomere, troponin I (TnI) plays a key role in regulating the Ca(2+) sensitivity of force. During myocardial development, there is a transition in TnI isoform expression from the slow skeletal isoform (ssTnI) in embryonic/
Margaret V. Westfall, Joseph M. Metzger
openaire   +3 more sources

Isoform abundance inference provides a more accurate estimation of gene expression levels in RNA-seq.

Journal of Bioinformatics and Computational Biology, 2010
Due to its unprecedented high-resolution and detailed information, RNA-seq technology based on next-generation high-throughput sequencing significantly boosts the ability to study transcriptomes.
Xi Wang, Zhengpeng Wu, Xuegong Zhang
semanticscholar   +1 more source

Multiple New Isoforms of the Human Prolactin Receptor Gene

2004
Prolactin (PRL) is a polypeptide hormone with a clear role in promoting mammary gland growth, differentiation, and lactogenesis. In addition, endocrine and/or autocrine/ paracrine PRL (Clevenger et al. 1995; Ginsburg & Vonderhaar 1995) promotes mammary carcinogenesis in rodents (Wennbo et al.
Josephine F. Trott, Sailaja Koduri, Russell C. Hovey, Barbara K. Vonderhaar   +3 more
openaire   +3 more sources

Characterization of the activation-associated isoform of CD43 on murine T lymphocytes.

Journal of Immunology, 1994
A rat mAb termed 1B11 recognizes a 130-kDa cell surface glycoprotein expressed on T lymphocytes. Transfection studies using the Cd43 gene transfected into murine L cells, and immunoblots using anti-peptide Abs specific for the CD43 polypeptide identified
A. Jones, B. Federsppiel, L. Ellies, M. Williams, R. Burgener, V. Duronio, C. Smith, F. Takei, H. Ziltener   +8 more
semanticscholar   +1 more source

Differential gene expression of CYP3A isoforms in equine liver and intestines

Journal of Veterinary Pharmacology and Therapeutics, 2012
Tydén, E., Löfgren, M., Pegolo, S., Capolongo, F., Tjälve, H., Larsson, P. Differential gene expression of CYP3A isoforms in equine liver and intestines. J. vet. Pharmacol. Therap. 35, 588–595.Recently, seven CYP3A isoforms – CYP3A89, CYP3A93, CYP3A94, CYP3A95, CYP3A96, CYP3A97 and CYP129 – have been isolated from the horse genome.
Tydén E, Löfgren M, PEGOLO, SARA, CAPOLONGO, FRANCESCA, Tjälve H, Larsson P.   +5 more
openaire   +3 more sources

Prioritizing genes with functionally distinct splice isoforms

2020
Most mammalian genes generate multiple transcripts via splicing, and we do not know the function of most splice variants. Currently, there is a debate about how many splice variants are likely nonfunctional or “noisy” transcripts. My thesis explores the claim that alternative splicing vastly increases the genome’s functional diversity in the context of
openaire   +2 more sources

Roles of the BRD4 short isoform in phase separation and active gene transcription

Nature Structural & Molecular Biology, 2020
Xinye Han, Di Yu, Ruirui Gu, Y. Jia, Qi Wang, Anbalagan Jaganathan, Xuelan Yang, Miaomiao Yu, N. Babault, Chengcheng Zhao, H. Yi, Qiang Zhang, Ming-Ming Zhou, L. Zeng   +13 more
semanticscholar   +1 more source

Improving gene isoform quantification with miniQuant.

Nature Biotechnology
Haoran Li, Dingjie Wang, Qi Gao, Puwen Tan, Yunhao Wang, Xiaoyu Cai, Aifu Li, Yue Zhao, Andrew L Thurman, S. A. Malekpour, Ying Zhang, Roberta Sala, Andrea Cipriano, Chia-Lin Wei, V. Sebastiano, Chi Song, Nancy R. Zhang, Kin Fai Au   +17 more
semanticscholar   +1 more source

Identification of Multiple Isoforms of the Ashwin Gene in Cattle.

Biology of Reproduction, 2010
Verónica Moreno-Brito, Elier Soto-Orduno, Eduviges Burrola-Barraza, Ernesto Orozco-Lucero, Ruth Lechuga-Valles, Everardo González-Rodríguez, Moises Barcelo-Fimbres, Irene Leal-Berumen   +7 more
openaire   +2 more sources