Results 31 to 40 of about 7,252,476 (351)

Dual RNA 3’-end processing of H2A.X messenger RNA maintains DNA damage repair throughout the cell cycle

Nature Communications, 2021
H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X ...
Esther Griesbach, Margarita Schlackow, William F. Marzluff, Nick J. Proudfoot   +3 more
doaj   +1 more source

Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2

Cell Reports, 2019
Summary: Alternative translation is an important mechanism of post-transcriptional gene regulation leading to the expression of different protein isoforms originating from the same mRNA.
Philipp Trulley, Goda Snieckute, Dorte Bekker-Jensen, Manoj B. Menon, Robert Freund, Alexey Kotlyarov, Jesper V. Olsen, Manuel D. Diaz-Muñoz, Martin Turner, Simon Bekker-Jensen, Matthias Gaestel, Christopher Tiedje   +11 more
doaj   +1 more source

Obstacles to detecting isoforms using full-length scRNA-seq data

Genome Biology, 2020
Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples.
Jennifer Westoby, Pavel Artemov, Martin Hemberg, Anne Ferguson-Smith   +3 more
doaj   +1 more source

Influence of Temperature, Hypercapnia, and Development on the Relative Expression of Different Hemocyanin Isoforms in the Common Cuttlefish Sepia officinalis [PDF]

, 2012
The cuttlefish Sepia officinalis expresses several hemocyanin isoforms with potentially different pH optima, indicating their reliance on efficient pH regulation in the blood.
Gutowska, Magdalena A., Hu, Marian Y.A., Lieb, Bernhard, Lucassen, Magnus, Mark, Felix Christopher, Melzner, Frank, Pörtner, Hans-Otto, Strobel, Anneli   +7 more
core   +1 more source

HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers

Cell Reports, 2019
Summary: Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad functional diversity is unknown. Here, we show that inflammation and immune pathway genes
Hui Ling Ko, Ziyi Zhuo, Ee Chee Ren
doaj   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Cloning and characterisation of multiple ferritin isoforms in the Atlantic salmon (Salmo salar) [PDF]

, 2014
Peer reviewedPublisher ...
Lee, Jun Hoe, Martin, Samuel A M, Mohd-Adnan, Adura, Pooley, Nicholas J.   +3 more
core   +8 more sources

C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia [PDF]

, 2015
Accumulating evidences indicate that different long non-coding RNAs (lncRNAs) might play a relevant role in tumorigenesis, with their expression and function already associated to cancer development and progression.
Bozzoni, Irene, Fatica, Alessandro, Fazi, Francesco, Hughes, JAMES M., Legnini, Ivano, Marchioni, M, Masciarelli, Silvia, Morlando, Mariangela, Salvatori, Beatrice   +8 more
core   +2 more sources

Bovine C-X-C Motif Chemokine Ligand 14 Expression Is Regulated by Alternative Polyadenylation and MicroRNAs

Animals, 2023
Alternative polyadenylation (APA), including APA that occurs only in the 3′ UTR (3′ UTR-APA), is an important post-transcriptional regulatory mechanism that leads to distinct 3′ UTRs for some genes, increasing the complexity of the transcriptome.
Wei Zhao, Xueyan Liu, Chengping Li, Xuyong Qin, Shizhong Ren, Shujun Cao, Guoli Zhou   +6 more
doaj   +1 more source

Oleoyl-CoA Is the Major de Novo Product of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2,3-diacylglycerol*

Journal of Biological Chemistry, 2001
1-Alkyl-2,3-diacylglycerol (ADG) is a unique neutral lipid found in the eyeball-associated Harderian gland (HG) of the mouse and acts as a lubricant to facilitate eyelid movement.
M. Miyazaki, Hyoun-ju Kim, W. C. Man, J. Ntambi   +3 more
semanticscholar   +1 more source