Results 31 to 40 of about 413,820 (357)
Obstacles to detecting isoforms using full-length scRNA-seq data
Genome Biology, 2020 Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples.
Jennifer Westoby +3 more
doaj +1 more source
Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. [PDF]
, 2014 Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a ...
Bi, Yingtao +5 more
core +1 more source
The Coevolution of Insect Muscle TpnT and TpnI Gene Isoforms [PDF]
Molecular Biology and Evolution, 2005 In bilaterians, the main regulator of muscle contraction is the troponin (Tpn) complex, comprising three closely interacting subunits (C, T, and I). To understand how evolutionary forces drive molecular change in protein complexes, we have compared the gene structures and expression patterns of Tpn genes in insects. In this class, while TpnC is encoded
Herranz, Raúl +5 more
openaire +4 more sources
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Computational and Structural Biotechnology Journal, 2021 Transcript isoforms regulated by alternative splicing can substantially impact carcinogenesis, leading to a need to obtain clues for both gene differential expression and malfunctions of isoform distributions in cancer studies.
Tzu-Hsien Yang +8 more
doaj
One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]
, 2017 Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
core +1 more source
Novel Chicken Actin Gene: Third Cytoplasmic Isoform [PDF]
Molecular and Cellular Biology, 1985 We identified a novel chicken actin gene. The actin protein deduced from its nucleotide sequence very closely resembles the vertebrate cytoplasmic actins; accordingly, we classified this gene as a nonmuscle type. We adopted the convention for indicating the nonmuscle actins of the class Amphibia (Vandekerckhove et al., J. Mol. Biol.
R. J. Schwartz +2 more
openaire +3 more sources
PLoS Computational Biology, 2013 Integrating large-scale functional genomic data has significantly accelerated our understanding of gene functions. However, no algorithm has been developed to differentiate functions for isoforms of the same gene using high-throughput genomic data.
Ridvan Eksi +6 more
doaj +1 more source
Integrating splice-isoform expression into genome-scale models characterizes breast cancer metabolism [PDF]
Bioinformatics, btx562, 34(3):494-501, 2018, 2018 Motivation: Despite being often perceived as the main contributors to cell fate and physiology, genes alone cannot predict cellular phenotype. During the process of gene expression, 95% of human genes can code for multiple proteins due to alternative splicing.
arxiv +1 more source
Paraoxonase 2 protein is spatially expressed in the human placenta and selectively reduced in labour [PDF]
, 2014 Humans parturition involves interaction of hormonal, neurological, mechanical stretch and inflammatory pathways and the placenta plays a crucial role.
A Abdulsid +32 more
core +8 more sources