Results 31 to 40 of about 6,900,738 (371)
Nature Communications, 2021 H2A.X histone variant gene encodes poly(A)+ and poly(A)- mRNA isoforms which are differentially expressed depending on cell lines. Here the authors show that upon DNA damage, cells expressing more poly(A)+ isoform require this isoform for de novo H2A.X ...
Esther Griesbach +3 more
doaj +1 more source
Kinetochore inactivation by expression of a repressive mRNA. [PDF]
, 2017 Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes.
Chen, Jingxun +8 more
core +2 more sources
OncoTarget, 2017 Glioblastoma is the most common type of malignant primary brain tumor and has high recurrence and lethality rates. Glioblastoma stem cells (GSCs), a subpopulation of glioblastoma cells, may promote rapid tumor recurrence and therapy resistance.
Zhuo Xi +9 more
semanticscholar +1 more source
Discovery of two new isoforms of the human DUT gene
Scientific Reports, 2023 AbstractIn human cells two dUTPase isoforms have been described: one nuclear (DUT-N) and one mitochondrial (DUT-M), with cognate localization signals. In contrast, here we identified two additional isoforms; DUT-3 without any localization signal and DUT-4 with the same nuclear localization signal as DUT-N.
Gergely Attila Rácz +5 more
openaire +3 more sources
The p52 isoform of SHC1 is a key driver of breast cancer initiation
Breast Cancer Research, 2019 Background SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer.
Kevin D. Wright +11 more
doaj +1 more source
Obstacles to detecting isoforms using full-length scRNA-seq data
Genome Biology, 2020 Background Early single-cell RNA-seq (scRNA-seq) studies suggested that it was unusual to see more than one isoform being produced from a gene in a single cell, even when multiple isoforms were detected in matched bulk RNA-seq samples.
Jennifer Westoby +3 more
doaj +1 more source
The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
Cancer Cell International, 2021 Background Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased expression of DLG2, a gene residing
Simon Keane +3 more
doaj +1 more source
Isoform-specific functions of PPARγ in gene regulation and metabolism
Genes & Development, 2022 Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by antidiabetic thiazolidinediones (TZD) reverses insulin resistance but also leads to weight gain that limits the use of these drugs. There are two main PPARγ isoforms, but
Hu, Wenxiang +11 more
openaire +3 more sources
Computational and Structural Biotechnology Journal, 2021 Transcript isoforms regulated by alternative splicing can substantially impact carcinogenesis, leading to a need to obtain clues for both gene differential expression and malfunctions of isoform distributions in cancer studies.
Tzu-Hsien Yang +8 more
doaj
Isoform-level gene signature improves prognostic stratification and accurately classifies glioblastoma subtypes. [PDF]
, 2014 Molecular stratification of tumors is essential for developing personalized therapies. Although patient stratification strategies have been successful; computational methods to accurately translate the gene-signature from high-throughput platform to a ...
Bi, Yingtao +5 more
core +1 more source