The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]
, 2012 Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama +39 more
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MSIQ: Joint Modeling of Multiple RNA-seq Samples for Accurate Isoform Quantification
, 2017 Next-generation RNA sequencing (RNA-seq) technology has been widely used to assess full-length RNA isoform abundance in a high-throughput manner. RNA-seq data offer insight into gene expression levels and transcriptome structures, enabling us to better ...
Li, Jingyi Jessica +3 more
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Transcription of a 5' extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter. [PDF]
, 2017 Cell differentiation programs require dynamic regulation of gene expression. During meiotic prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit Ndc80 is downregulated by a 5' extended long undecoded NDC80 transcript ...
Chen, Jingxun +6 more
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IsoResolve: predicting splice isoform functions by integrating gene and isoform-level features with domain adaptation [PDF]
Bioinformatics, 2020 AbstractMotivationHigh resolution annotation of gene functions is a central goal in functional genomics. A single gene may produce multiple isoforms with different functions through alternative splicing. Conventional approaches, however, consider a gene as a single entity without differentiating these functionally different isoforms.
Hong-Dong Li +6 more
openaire +2 more sources
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana +11 more
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Isoform-Specific Imprinting of the Human PEG1/MEST Gene [PDF]
The American Journal of Human Genetics, 2000 We thank Mr. Taichi Suzuki, from Tokyo Technical College, for excellent laboratory assistance. This work was supported, in part, by a grant from the Pharmacia-Upjohn Fund for Growth & Development Research.
Kosaki, Kenjiro +3 more
openaire +2 more sources
Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.
PLoS ONE, 2015 Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome.
Sarah Leigh-Brown +8 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2022 The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun +6 more
doaj +1 more source
Tissue resolved, gene structure refined equine transcriptome. [PDF]
, 2017 BackgroundTranscriptome interpretation relies on a good-quality reference transcriptome for accurate quantification of gene expression as well as functional analysis of genetic variants.
Bellone, RR +9 more
core +1 more source
PLoS ONE, 2012 CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC.
Mari H Tervaniemi +10 more
doaj +1 more source