Results 41 to 50 of about 7,252,476 (351)

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama, A Zipursky, AG Muntean, AG Muntean, Brenda Gibson, C Halsey, C Kuhl, Christina Halsey, CS McKimmie, Derek Gilchrist, Gerard Graham, H Sakamoto, I Matsumura, J Wechsler, JD Crispino, JP Bourquin, K Georgopoulos, KA Alford, L Gutierrez, LC Andersson, LM Hollanda, M Ritter, Marie Docherty, ME Greene, Mhairi McNeill, Michelle Le Brocq, N Shimokawa, N Suzuki, N Ueki, O Tunstall-Pedoe, PA Tetteroo, R Alitalo, R Calligaris, R Ferreira, RA Shivdasani, S Pearson-White, S Teichler, T Nomura, Y Ge, Z Li   +39 more
core   +2 more sources

ZIKV infection effects changes in gene splicing, isoform composition and lncRNA expression in human neural progenitor cells

Virology Journal, 2017
BackgroundThe Zika virus (ZIKV) is a mosquito-borne flavivirus that causes microcephaly and Guillain-Barré syndrome in infected individuals. To obtain insights into the mechanism of ZIKV infection and pathogenesis, we analyzed the transcriptome of ZIKV ...
Benxia Hu, Yongxia Huo, Liping Yang, Guijun Chen, M. Luo, Jinlong Yang, Jumin Zhou   +6 more
semanticscholar   +1 more source

Isoform cell-type specificity in the mouse primary motor cortex

Nature, 2020
Full-length SMART-seq1 single-cell RNA sequencing can be used to measure gene expression at isoform resolution, making possible the identification of specific isoform markers for different cell types. Used in conjunction with spatial RNA capture and gene-
A. S. Booeshaghi, Zizhen Yao, Cindy T. J. van Velthoven, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng, L. Pachter   +6 more
semanticscholar   +1 more source

Single-cell RNA counting at allele and isoform resolution using Smart-seq3

Nature Biotechnology, 2019
Large-scale sequencing of RNA from individual cells can reveal patterns of gene, isoform and allelic expression across cell types and states1. However, current short-read single-cell RNA-sequencing methods have limited ability to count RNAs at allele and
Michael Hagemann-Jensen, C. Ziegenhain, Ping Chen, D. Ramsköld, Gert-Jan Hendriks, Anton J. M. Larsson, O. Faridani, R. Sandberg   +7 more
semanticscholar   +1 more source

MSIQ: Joint Modeling of Multiple RNA-seq Samples for Accurate Isoform Quantification

, 2017
Next-generation RNA sequencing (RNA-seq) technology has been widely used to assess full-length RNA isoform abundance in a high-throughput manner. RNA-seq data offer insight into gene expression levels and transcriptome structures, enabling us to better ...
Li, Jingyi Jessica, Li, Wei Vivian, Zhang, Shihua, Zhao, Anqi   +3 more
core   +2 more sources

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]

, 2018
FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang, Wang, Qun, Zhou, Baohua, Ziegler, Steven F.   +3 more
core   +1 more source

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Science, 2018
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags behind other fields of medicine.
M. Gandal, Pan Zhang, Evi Hadjimichael, R. Walker, Chao Chen, Shuang Liu, H. Won, H. van Bakel, M. Varghese, Yongjun Wang, Annie W Shieh, J. Haney, Sepideh Parhami, Judson Belmont, Minsoo Kim, Patricia Moran Losada, Z. Khan, J. Mleczko, Yan Xia, R. Dai, Daifeng Wang, Yucheng T. Yang, Min Xu, K. Fish, P. Hof, J. Warrell, Dominic Fitzgerald, K. White, A. Jaffe, M. Peters, M. Gerstein, Chunyu Liu, L. Iakoucheva, D. Pinto, D. Geschwind   +34 more
semanticscholar   +1 more source

Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway

Computational and Structural Biotechnology Journal, 2022
The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun, Lu Li, Jiameng Hu, Yan Gao, Jinyi Song, Xiang Zhang, Haiyang Hu   +6 more
doaj   +1 more source

Tissue resolved, gene structure refined equine transcriptome. [PDF]

, 2017
BackgroundTranscriptome interpretation relies on a good-quality reference transcriptome for accurate quantification of gene expression as well as functional analysis of genetic variants.
Bellone, RR, Brown, CT, Finno, CJ, Mansour, TA, Mienaltowski, MJ, Murray, JD, Penedo, MC, Ross, PJ, Scott, EY, Valberg, SJ   +9 more
core   +1 more source

Alternative Isoform Regulation in Human Tissue Transcriptomes

Nature, 2008
Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms that may have related, distinct or even opposing functions.
Eric T. Wang, R. Sandberg, Shujun J Luo, I. Khrebtukova, Lu Zhang, C. Mayr, S. Kingsmore, G. Schroth, C. Burge   +8 more
semanticscholar   +1 more source