Results 51 to 60 of about 7,252,476 (351)

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

PLoS ONE, 2015
Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome.
Sarah Leigh-Brown, Angela Goncalves, David Thybert, Klara Stefflova, Stephen Watt, Paul Flicek, Alvis Brazma, John C Marioni, Duncan T Odom   +8 more
doaj   +1 more source

Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization.

PLoS ONE, 2012
CCHCR1 (Coiled-Coil α-Helical Rod protein 1), within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene with the psoriasis associated risk allele CCHCR1*WWCC.
Mari H Tervaniemi, H Annika Siitonen, Cilla Söderhäll, Gurinder Minhas, Jyrki Vuola, Inkeri Tiala, Raija Sormunen, Lena Samuelsson, Sari Suomela, Juha Kere, Outi Elomaa   +10 more
doaj   +1 more source

Expand+Functional selection and systematic analysis of intronic splicing elements identify active sequence motifs and associated splicing factors [PDF]

, 2010
Despite the critical role of pre-mRNA splicing in generating proteomic diversity and regulating gene expression, the sequence composition and function of intronic splicing regulatory elements (ISREs) have not been well elucidated.
Berglund, J. Andrew, Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D., Voelker, Rodger B.   +4 more
core   +4 more sources

Only one isoform of Drosophila melanogaster CTP synthase forms the cytoophidium.

PLoS Genetics, 2013
CTP synthase is an essential enzyme that plays a key role in energy metabolism. Several independent studies have demonstrated that CTP synthase can form an evolutionarily conserved subcellular structure termed cytoophidium.
Ghows Azzam, Ji-Long Liu
doaj   +1 more source

Evolution of oleosin in land plants. [PDF]

PLoS ONE, 2014
Oleosins form a steric barrier surface on lipid droplets in cytoplasm, preventing them from contacting and coalescing with adjacent droplets. Oleosin genes have been detected in numerous plant species.
Yuan Fang, Rui-Liang Zhu, Brent D Mishler   +2 more
doaj   +1 more source

FreePSI: an alignment-free approach to estimating exon-inclusion ratios without a reference transcriptome. [PDF]

, 2017
Alternative splicing plays an important role in many cellular processes of eukaryotic organisms. The exon-inclusion ratio, also known as percent spliced in, is often regarded as one of the most effective measures of alternative splicing events.
Jiang, Tao, Ma, Shining, Wang, Dongfang, Zeng, Jianyang, Zhou, Jianyu   +4 more
core   +1 more source

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

PLoS ONE, 2012
Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the ...
J. Salzman, Charles Gawad, Peter L Wang, Norman J. Lacayo, P. Brown   +4 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane [PDF]

, 2019
Alternative Splicing (AS) is a mechanism that generates different mature transcripts from precursor mRNAs (pre-mRNAs) of the same gene. In plants, a wide range of physiological and metabolic events are related to AS, as well as fast responses to changes ...
Alabadí, Amorim, Annunziata, Annunziata, Beyer, Bieniawska, Calixto, Calixto, Calixto, Calixto, Chamala, Chan, Chaudhary, Cuadrado, Dantas, de Setta, Ding, Dodd, Dodd, D’Hont, D’Hont, Endo, Filichkin, Filichkin, Filichkin, Filichkin, Fouquet, Frank, Fung-Uceda, Garcia, Garsmeur, Godoy Herz, Graf, Graf, Graveley, Grundy, Göhring, Harmer, Haydon, Higashi, Hotta, Hsu, Iskandar, Izawa, Izawa, Jabre, Jacob, James, James, James, Jones, Kalyna, Khan, Ko, Kornblihtt, Kriechbaumer, Kwon, Lai, Liu, Locke, Lu, Marquez, Marshall, Mastrangelo, McClung, McCormick, Millar, Miller, Min, Moll, Moore, Murakami, Nagano, Nagashima, Nakamichi, Ng, Ni, Oesterreich, Palusa, Para, Park, Pokhilko, Reddy, Remy, Riaño-Pachón, Richards, Rosloski, Saldi, Sato, Seo, Seo, Severing, Shalit-Kaneh, Shang, Shen, Simpson, Simpson, Souza, Staiger, Staiger, Sugliani, Syed, Szakonyi, Thatcher, Vaneechoutte, Vicentini, Wang, Zeilinger, Zhang, Zhang, Zhang, Zhang   +111 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source