Results 51 to 60 of about 413,820 (357)

BIISQ: Bayesian nonparametric discovery of Isoforms and Individual Specific Quantification [PDF]

, 2017
Most human protein-coding genes can be transcribed into multiple possible distinct mRNA isoforms. These alternative splicing patterns encourage molecular diversity and dysregulation of isoform expression plays an important role in disease etiology. However, isoforms are difficult to characterize from short-read RNA-seq data because they share identical
arxiv   +1 more source

Isoform-specific functions of PPARγ in gene regulation and metabolism

Genes & Development, 2022
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that is a vital regulator of adipogenesis, insulin sensitivity, and lipid metabolism. Activation of PPARγ by antidiabetic thiazolidinediones (TZD) reverses insulin resistance but also leads to weight gain that limits the use of these drugs. There are two main PPARγ isoforms, but
Hu, Wenxiang, Jiang, Chunjie, Kim, Mindy, Xiao, Yang, Richter, Hannah J., Guan, Dongyin, Zhu, Kun, Krusen, Brianna M., Roberts, Arielle N., Miller, Jessica, Steger, David J., Lazar, Mitchell A.   +11 more
openaire   +2 more sources

Expression and splicing mediate distinct biological signals

BMC Biology, 2023
Background Through alternative splicing, most human genes produce multiple isoforms in a cell-, tissue-, and disease-specific manner. Numerous studies show that alternative splicing is essential for development, diseases, and their treatments.
Søren Helweg Dam, Lars Rønn Olsen, Kristoffer Vitting-Seerup   +2 more
doaj   +1 more source

The contribution of Alu exons to the human proteome. [PDF]

, 2016
BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng, Lam, Maggie PY, Lin, Lan, Lu, Zhi-Xiang, Park, Juw Won, Ping, Peipei, Wang, Jinkai, Xing, Yi   +7 more
core   +1 more source

SLMAP3 isoform modulates cardiac gene expression and function

PLOS ONE, 2019
The sarcolemmal membrane associated proteins (SLMAPs) belong to the super family of tail anchored membrane proteins which serve diverse roles in biology including cell growth, protein trafficking and ion channel regulation. Mutations in human SLMAP have been linked to Brugada syndrome with putative deficits in trafficking of the sodium channel (Nav1.5)
Jana Mlynarova, Mayra Trentin-Sonoda, Fernanda Gaisler da Silva, Jennifer L. Major, Maysoon Salih, Marcela S. Carneiro-Ramos, Balwant S. Tuana   +6 more
openaire   +4 more sources

Computational identification of transcriptionally co-regulated genes, validation with the four ANT isoform genes [PDF]

BMC Genomics, 2012
Abstract Background The analysis of gene promoters is essential to understand the mechanisms of transcriptional regulation required under the effects of physiological processes, nutritional intake or pathologies. In higher eukaryotes, transcriptional regulation implies the recruitment of a set of regulatory proteins ...
Pierre-Yves Dupont, Pierre-Yves Dupont, Georges Stepien, Georges Stepien, Jean-Paul Issartel, Audrey Guttin   +5 more
openaire   +8 more sources

Gene isoform specificity through enhancer-associated antisense transcription. [PDF]

PLoS ONE, 2012
Enhancers and antisense RNAs play key roles in transcriptional regulation through differing mechanisms. Recent studies have demonstrated that enhancers are often associated with non-coding RNAs (ncRNAs), yet the functional role of these enhancer:ncRNA ...
Courtney S Onodera, Jason G Underwood, Sol Katzman, Frank Jacobs, David Greenberg, Sofie R Salama, David Haussler   +6 more
doaj   +1 more source

Network-based Isoform Quantification with RNA-Seq Data for Cancer Transcriptome Analysis [PDF]

, 2014
High-throughput mRNA sequencing (RNA-Seq) is widely used for transcript quantification of gene isoforms. Since RNA-Seq data alone is often not sufficient to accurately identify the read origins from the isoforms for quantification, we propose to explore protein domain-domain interactions as prior knowledge for integrative analysis with RNA-seq data. We
arxiv   +1 more source

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

Genome Biology, 2021
Introduction Genes contain multiple promoters that can drive the expression of various transcript isoforms. Although transcript isoforms from the same gene could have diverse and non-overlapping functions, current loss-of-function methodologies are not ...
Rebecca Davies, Ling Liu, Sheng Taotao, Natasha Tuano, Richa Chaturvedi, Kie Kyon Huang, Catherine Itman, Amit Mandoli, Aditi Qamra, Changyuan Hu, David Powell, Roger J. Daly, Patrick Tan, Joseph Rosenbluh   +13 more
doaj   +1 more source

Prediction of regulatory targets of alternative isoforms of the epidermal growth factor receptor in a glioblastoma cell line. [PDF]

, 2019
BackgroundThe epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a variety of tumor types. There are at least
Ardell, David H, Eckert, Alexander W, Grosse, Ivo, Kappler, Matthias, Kotrba, Johanna, Vordermark, Dirk, Weinholdt, Claus, Wichmann, Henri   +7 more
core   +3 more sources