Results 61 to 70 of about 6,900,738 (371)

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System.

PLoS ONE, 2015
Phenotypic differences between species are driven by changes in gene expression and, by extension, by modifications in the regulation of the transcriptome.
Sarah Leigh-Brown, Angela Goncalves, David Thybert, Klara Stefflova, Stephen Watt, Paul Flicek, Alvis Brazma, John C Marioni, Duncan T Odom   +8 more
doaj   +1 more source

Evolution of oleosin in land plants. [PDF]

PLoS ONE, 2014
Oleosins form a steric barrier surface on lipid droplets in cytoplasm, preventing them from contacting and coalescing with adjacent droplets. Oleosin genes have been detected in numerous plant species.
Yuan Fang, Rui-Liang Zhu, Brent D Mishler   +2 more
doaj   +1 more source

MSIQ: Joint Modeling of Multiple RNA-seq Samples for Accurate Isoform Quantification

, 2017
Next-generation RNA sequencing (RNA-seq) technology has been widely used to assess full-length RNA isoform abundance in a high-throughput manner. RNA-seq data offer insight into gene expression levels and transcriptome structures, enabling us to better ...
Li, Jingyi Jessica, Li, Wei Vivian, Zhang, Shihua, Zhao, Anqi   +3 more
core   +2 more sources

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT [PDF]

, 2011
Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFß-dependent biological outputs such as epithelial–mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase
A Chantry, A Hata, CH Heldin, CS Lutz, D Javelaud, F Bernassola, F Murray-Zmijewski, FJ McDonald, G Pirozzi, H Li, H Xu, H Zhu, HM Xu, J Tazi, J Xu, J Zavadil, L Levy, M Flasza, NJ Foot, NS Raikwar, P Kavsak, P Lönn, PJ Lu, S Bonni, S Danckwardt, S Hong, S M Soond, S Wicks, S Wiesner, S Zhang, T Atsumi, T Mund, TW Nilsen, U Valcourt, V Ellenrieder, W Li   +35 more
core   +1 more source

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

Genome Biology, 2021
Introduction Genes contain multiple promoters that can drive the expression of various transcript isoforms. Although transcript isoforms from the same gene could have diverse and non-overlapping functions, current loss-of-function methodologies are not ...
Rebecca Davies, Ling Liu, Sheng Taotao, Natasha Tuano, Richa Chaturvedi, Kie Kyon Huang, Catherine Itman, Amit Mandoli, Aditi Qamra, Changyuan Hu, David Powell, Roger J. Daly, Patrick Tan, Joseph Rosenbluh   +13 more
doaj   +1 more source

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

PLoS ONE, 2012
Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the ...
J. Salzman, Charles Gawad, Peter L Wang, Norman J. Lacayo, P. Brown   +4 more
semanticscholar   +1 more source

SLMAP3 isoform modulates cardiac gene expression and function

PLOS ONE, 2019
The sarcolemmal membrane associated proteins (SLMAPs) belong to the super family of tail anchored membrane proteins which serve diverse roles in biology including cell growth, protein trafficking and ion channel regulation. Mutations in human SLMAP have been linked to Brugada syndrome with putative deficits in trafficking of the sodium channel (Nav1.5)
Jana Mlynarova, Mayra Trentin-Sonoda, Fernanda Gaisler da Silva, Jennifer L. Major, Maysoon Salih, Marcela S. Carneiro-Ramos, Balwant S. Tuana   +6 more
openaire   +4 more sources

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells

Haematologica, 2017
The forkhead transcription factor FOXP1 is generally regarded as an oncogene in activated B cell-like diffuse large B-cell lymphoma. Previous studies have suggested that a small isoform of FOXP1 rather than full-length FOXP1, may possess this oncogenic ...
Martine van Keimpema, Leonie J. Grüneberg, Esther J.M. Schilder-Tol, Monique E.C.M. Oud, Esther A. Beuling, Paul J. Hensbergen, Johann de Jong, Steven T. Pals, Marcel Spaargaren   +8 more
doaj   +1 more source

Tissue resolved, gene structure refined equine transcriptome. [PDF]

, 2017
BackgroundTranscriptome interpretation relies on a good-quality reference transcriptome for accurate quantification of gene expression as well as functional analysis of genetic variants.
Bellone, RR, Brown, CT, Finno, CJ, Mansour, TA, Mienaltowski, MJ, Murray, JD, Penedo, MC, Ross, PJ, Scott, EY, Valberg, SJ   +9 more
core   +1 more source

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. [PDF]

, 2016
Overexpression and/or hyperactivation of cyclin-dependent kinases (CDKs) are common features of most cancer types. CDKs have been shown to play important roles in tumor cell proliferation and growth by controlling cell cycle, transcription, and RNA ...
Duan, Zhenfeng, Hornicek, Francis J, Kan, Quancheng, Shen, Jacson K, Zhou, Yubing   +4 more
core   +1 more source