A Strategy for Gene Knockdown in Dinoflagellates [PDF]
Microorganisms, 2022 Dinoflagellates are unicellular protists that display unusual nuclear features such as large genomes, condensed chromosomes and multiple gene copies organized as tandem gene arrays.
Miranda Judd, Allen R. Place
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Cathepsin B-activatable cyclic antisense oligonucleotides for cell-specific target gene knockdown in vitro and in vivo [PDF]
Molecular Therapy: Nucleic Acids, 2023 Trigger-activatable antisense oligonucleotides have been widely applied to regulate gene function. Among them, caged cyclic antisense oligonucleotides (cASOs) maintain a specific topology that temporarily inhibits their interaction with target genes.
Zhongyu Wang +6 more
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Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells [PDF]
Molecular Therapy: Nucleic Acids, 2023 Trans-acting hammerhead ribozyme inherits the advantages of being the smallest and best-characterized RNA-cleaving ribozyme, offering high modularity and the ability to cleave any desired sequence without the aid of any protein, as long as the target ...
Shan Zhou +11 more
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Specific adipose tissue Lbp gene knockdown prevents diet-induced body weight gain, impacting fat accretion-related gene and protein expression [PDF]
Molecular Therapy: Nucleic Acids, 2022 Lipopolysaccharide binding protein (Lbp) has been recently identified as a relevant component of innate immunity response associated to adiposity. Here, we aimed to investigate the impact of adipose tissue Lbp on weight gain and white adipose tissue (WAT)
Jessica Latorre +11 more
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Effects of Ventromedial Hypothalamic Nucleus (VMN) Aromatase Gene Knockdown on VMN Glycogen Metabolism and Glucoregulatory Neurotransmission [PDF]
Biology, 2023 The enzyme aromatase is expressed at high levels in the ventromedial hypothalamic nucleus (VMN), a principal component of the brain gluco-regulatory network.
Karen P. Briski +4 more
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Calcineurin Aβ gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte. [PDF]
Open Life Sci, 2021 Yang L +7 more
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Effect of using amino acids in the freeze-drying of siRNA lipoplexes on gene knockdown in cells after reverse transfection. [PDF]
Biomed Rep, 2021 Tang M, Hattori Y.
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Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver. [PDF]
Protein Cell, 2020 He B +11 more
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Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment. [PDF]
Signal Transduct Target TherJohnston M, Urban N, Dincer C.
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Animals, 2021 The endoplasmic reticulum (ER) is an organelle important for several functions of cellular physiology. This study identified the giant river prawn’s glucose-regulated protein 78 (Mr-grp78), which is important for ER stress mechanisms.
Prapansak Srisapoome +2 more
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