Results 101 to 110 of about 405,164 (304)

The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes [PDF]

, 2022
Jèssica Latorre, Ángeles Aroca, José Manuel Fernández‐Real, Luís C. Romero, José María Moreno‐Navarrete   +4 more
openalex   +1 more source

Gene knockdown in malaria parasites via non-canonical RNAi

Nucleic Acids Research, 2019
Abstract The lack of endogenous RNAi machinery in the malaria parasite Plasmodium hampers gene annotation and hence antimalarial drug and vaccine development. Here, we engineered rodent Plasmodium berghei to express a minimal, non-canonical RNAi machinery that solely requires Argonaute 2 (Ago2) and a modified short hairpin RNA, so-called
Franziska Hentzschel, Vera Mitesser, Sabine Anne-Kristin Fraschka, Daria Krzikalla, Elena Herrera Carrillo, Ben Berkhout, Richárd Bártfai, Ann-Kristin Mueller, Dirk Grimm   +8 more
openaire   +4 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Knockdown of Dyslexia-GeneDcdc2Interferes with Speech Sound Discrimination in Continuous Streams [PDF]

, 2016
Tracy M. Centanni, Anne B. Booker, Fuyi Chen, Andrew M. Sloan, Ryan S. Carraway, Robert L. Rennaker, Joseph J. LoTurco, Michael P. Kilgard   +7 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Gene Expression Knockdown by Modulating Synthetic Small RNA Expression in Escherichia coli [PDF]

, 2017
Minho Noh, Seung Min Yoo, Won Jun Kim, Sang Yup Lee   +3 more
openalex   +1 more source

Transcriptome changes in ERGIC3-knockdown hepatocellular carcinoma cells: ERGIC3 is a novel immune function related gene

, 2022
Mengyuan Liu, Qiurong Zhao, Xiang Zheng, Lei Yang, Yanyu Zhao, Xueying Li, Mingsong Wu   +6 more
openalex   +1 more source

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown [PDF]

, 2020
Sandra Noske, Michael Karimov, Achim Aigner, Alexander Ewe   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source