Results 131 to 140 of about 405,164 (304)

Designer gene knockdowns [PDF]

Nature, 2013
openaire   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos. [PDF]

Sci Rep, 2022
Masuda-Ozawa T, Fujita S, Nakamura R, Watanabe H, Kuranaga E, Nakajima YI.   +5 more
europepmc   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Ribozyme-Mediated Knockdown of lncRNA Gene Expression in Drosophila

Bio-Protocol
Long noncoding RNAs (lncRNAs) are increasingly understood to play important roles in cell biology, development, and disease, though the vast majority of annotated lncRNAs have yet to be functionally characterized.
Kevin Nyberg, Richard Carthew
doaj   +1 more source

Chloride intracellular channel gene knockdown induces insect cell lines death and level increases of intracellular calcium ions. [PDF]

Front Physiol, 2023
Song J, Yu Y, Yan Z, Xiao S, Zhao X, Wang F, Fang Q, Ye G.   +7 more
europepmc   +1 more source

Hippo Pathway Knockdown Gene Therapy in the Heart

Texas Heart Institute Journal, 2023
Heallen, Todd R., Martin, James F.
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Construction and application of the conditionally essential gene knockdown library in Klebsiella pneumoniae to screen potential antimicrobial targets and virulence genes via Mobile-CRISPRi-seq. [PDF]

Appl Environ Microbiol, 2023
Zhu Q, Lin Q, Jiang Y, Chen S, Tian J, Yang S, Li Y, Li M, Wang Y, Shen C, Meng S, Yang L, Feng Y, Qu J.   +13 more
europepmc   +1 more source

Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster [PDF]

С. В. Марфина, Elena A. Mikhaleva, Natalia Akulenko, Sergei Ryazansky   +3 more
openalex   +1 more source