Results 161 to 170 of about 405,164 (304)

ZIF Polymorphs for Nucleic Acid Delivery and Targeted Knockdown of Gene Expression in Prostate Cancer

, 2020
Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty, Ravi Shukla   +9 more
openalex   +1 more source

Peer Review #2 of "RNAi-based knockdown of candidate gut receptor genes altered the susceptibility of Spodoptera frugiperda and S. litura larvae to a chimeric toxin Cry1AcF (v0.1)"

, 2023
E Grizanova
openalex   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

RNA Interference-Mediated Knockdown of DNA Methyltransferase 1 Leads to Promoter Demethylation and Gene Re-Expression in Human Lung and Breast Cancer Cells [PDF]

, 2004
Makoto Suzuki, Noriaki Sunaga, David S. Shames, Shinichi Toyooka, Adi F. Gazdar, John D. Minna   +5 more
openalex   +1 more source

Optimal combination of cationic lipid and phospholipid in cationic liposomes for gene knockdown in breast cancer cells and mouse lung using siRNA lipoplexes. [PDF]

Mol Med Rep, 2022
Hattori Y, Tang M, Torii S, Tomita K, Sagawa A, Inoue N, Yamagishi R, Ozaki KI.   +7 more
europepmc   +1 more source

Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts

, 2016
Jian Ding, Zhiqiang Lin, Jianming Jiang, Christine E. Seidman, Jonathan G. Seidman, William T. Pu, Da‐Zhi Wang   +6 more
openalex   +1 more source

Postnatal knockdown of dok‐7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology [PDF]

, 2016
Takahiro Eguchi, Tohru Tezuka, Sadanori Miyoshi, Yuji Yamanashi   +3 more
openalex   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Efficient Gene Knockdown in Adult Zebrafish Retina by Intravitreal Injection. [PDF]

Bio Protoc
Shihabeddin E, Santhanam A, Tetenborg S, Aronowitz AL, O'Brien J.   +4 more
europepmc   +1 more source