Results 171 to 180 of about 405,164 (304)

Expression of Concern: RNAi Mediated Tiam1 Gene Knockdown Inhibits Invasion of Retinoblastoma. [PDF]

PLoS One, 2021
PLOS ONE Editors.
europepmc   +1 more source

Gene expression detection of epithelial and stromal cell-related proteins in ccRCC cells after overexpression or knockdown of DERL3 expression.

Chengtao Niu (21212827), Haodong Cui (3340506), Xintong Sun (17792071), Yuchang Yang (12633270), Xue Jiang (411020), Zixiang Cong (9117375), Yiming Zhang (444592), Zhihong Niu (835343), Wei He (131453)   +8 more
openalex   +1 more source

3P228 Identification and characterization of gravity sensing genes by gene knockdown and behavioural analysis

, 2004
Makoto Tsuda, Yosefu Arime, Kyoko Inada, Daisuke Sakurai, Tomoaki Horie, Takehiro Kusakabe, Yasuhiro Kohmura, Hisashi Ohtsuki   +7 more
openalex   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs. [PDF]

Int J Mol Sci
Golovkin I, Shatkovskii D, Serov N.
europepmc   +1 more source

Gold-Nanocluster-Mediated Delivery of siRNA to Intact Plant Cells for Efficient Gene Knockdown. [PDF]

Nano Lett, 2021
Zhang H, Cao Y, Xu D, Goh NS, Demirer GS, Cestellos-Blanco S, Chen Y, Landry MP, Yang P.   +8 more
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Microinjection, gene knockdown, and CRISPR-mediated gene knock-in in the hard coral, Astrangia poculata. [PDF]

Evodevo
Warner JF, Besemer R, Schickle A, Borbee E, Changsut IV, Sharp K, Babonis LS.   +6 more
europepmc   +1 more source

Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. [PDF]

Proc Natl Acad Sci U S A, 2021
Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman J.   +10 more
europepmc   +1 more source

Knockdown of BmorCPR67 gene disrupts prepupal–pupal transition of silkworm Bombyx mori by thinning the endocuticle [PDF]

Mingxing Jiang, Xiaoxuan Hu, Xu‐Dong Li, Qing Wang, Miao Shi, Ruirui Cui, Guoqing Wei, Lei Wang   +7 more
openalex   +1 more source