Results 181 to 190 of about 405,164 (304)

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

T14diLys/DOPE Liposomes: An Innovative Option for siRNA-Based Gene Knockdown? [PDF]

Pharmaceutics
Meinhard S, Erdmann F, Lucas H, Krabbes M, Krüger S, Wölk C, Mäder K.   +6 more
europepmc   +1 more source

Gene knockdown of CCR3 reduces eosinophilic inflammation and the Th2 immune response by inhibiting the PI3K/AKT pathway in allergic rhinitis mice. [PDF]

Sci Rep, 2022
Yuan J, Liu Y, Yu J, Dai M, Zhu Y, Bao Y, Peng H, Liu K, Zhu X.   +8 more
europepmc   +1 more source

Supplementary Material for: Transcriptional Changes following Cellular Knockdown of the Schizophrenia Risk Gene SETD1A Are Enriched for Common Variant Association with the Disorder

, 2019
Darren Cameron, Derek J. Blake, Nicholas J. Bray, Michael J. Hill   +3 more
openalex   +1 more source

Gene Expression Profiling of NFATc1-Knockdown in RAW 264.7 Cells: An Alternative Pathway for Macrophage Differentiation [PDF]

, 2019
Roberta Russo, Selene Mallia, Francesca Zito, Nadia Lampiasi   +3 more
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Effects of PTPN6 Gene Knockdown in SKM-1 Cells on Apoptosis, Erythroid Differentiation and Inflammations. [PDF]

Curr Issues Mol Biol
Yu L, Gu X, Chen P, Yang R, Xu Y, Yang X.   +5 more
europepmc   +1 more source

Oocyte-specific gene knockdown by intronic artificial microRNAs driven by Zp3 transcription in mice. [PDF]

J Reprod Dev, 2021
Sasaki K, Takaoka S, Obata Y.
europepmc   +1 more source

Regeneration of diabetic axons is enhanced by selective knockdown of the PTEN gene [PDF]

, 2014
Bhagat Singh, Vandana Singh, Anand Krishnan, Kurien Koshy, Jose A. Martinez, Chu Cheng, C. Christopher Almquist, Douglas W. Zochodne   +7 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source