Results 191 to 200 of about 405,164 (304)

Effects of sterol derivatives in cationic liposomes on biodistribution and gene-knockdown in the lungs of mice systemically injected with siRNA lipoplexes. [PDF]

Mol Med Rep, 2021
Hattori Y, Saito H, Oku T, Ozaki KI.
europepmc   +1 more source

HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes

, 2023
Lei Shi, Dehui� Zhang, Huijuan Han, Liangyu Zhang, Sirui Li, Fang� Yang, Caijun He   +6 more
openalex   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury. [PDF]

BMC Cardiovasc Disord
Wang J, Li Y, Li L, Liang H, Ye H, Kang P, Li Z, Yu Y, Gao Q.   +8 more
europepmc   +1 more source

Development of an RNA interference (RNAi) gene knockdown protocol in the anaerobic gut fungus Pecoramyces ruminantium strain C1A

, 2017
Shelby Calkins, Nicole C. Elledge, Stephen M. Marek, Matthew Brian Couger, Mostafa S. Elshahed, Noha H. Youssef   +5 more
openalex   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Protocol for odorant-binding protein 2A gene knockdown by dual siRNA transfection in a three-dimensional human epidermal equivalent model. [PDF]

STAR Protoc
Nakanishi S.
europepmc   +1 more source

RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content. [PDF]

Plant Cell Rep, 2021
Klein J, Horn E, Ernst M, Leykauf T, Leupold T, Dorfner M, Wolf L, Ignatova A, Kreis W, Munkert J.   +9 more
europepmc   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance. [PDF]

Int J Mol Sci
Pucci G, Minafra L, Bravatà V, Calvaruso M, Turturici G, Cammarata FP, Savoca G, Abbate B, Russo G, Cavalieri V, Forte GI.   +10 more
europepmc   +1 more source