Results 261 to 270 of about 405,164 (304)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Whole-transcriptome sequencing revealed the ceRNA regulatory network of stable knockdown of the CD8A gene in chicken T lymphocytes

Yanli Du, Ru Zhang, Meiquan Li, Xiao Wang, Hongyan Zhang, Bo Zhang, Bo Liao, Kun Wang, Xiannian Zi, Teng Huang, Changrong Ge, Jieyu Ma, Ling Li, Aiguo Xing   +13 more
openalex   +1 more source

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Effective targeted gene ‘knockdown’ in zebrafish

Nature Genetics, 2000
The sequencing of the zebrafish genome should be completed by the end of 2002. Direct assignment of function on the basis of this information would be facilitated by the development of a rapid, targeted 'knockdown' technology in this model vertebrate.
A, Nasevicius, S C, Ekker
openaire   +2 more sources

Targeted Knockdown of Genes in the Choroid Plexus

Journal of Visualized Experiments, 2023
The choroid plexus (ChP) serves as a critical gateway for immune cell infiltration into the central nervous system (CNS) under both physiological and pathological conditions. Recent research has shown that regulating ChP activity may offer protection against CNS disorders.
Yuwen, Yang, Chenxing, Qi, Lanxin, Hu, Cheng, Zheng, Xuhang, Li, Wu, Zheng, Yiyun, Weng, Haiyan, Lin   +7 more
openaire   +2 more sources

Gene Knockdown in Planarians Using RNA Interference

Cold Spring Harbor Protocols, 2008
INTRODUCTIONThis protocol describes how to produce gene knockdown in planarians using RNA interference (RNAi). It is a standard technique to evaluate gene function during regeneration and tissue maintenance in planarians. The procedure involves microinjecting double-stranded RNA (dsRNA) synthesized in vitro. Depending on the gene target, this technique
Néstor J, Oviedo, Cindy L, Nicolas, Dany S, Adams, Michael, Levin   +3 more
openaire   +2 more sources

Candidate Gene Knockdown in Celiac Disease

2015
RNA interference (RNAi) is a powerful genetic tool that has created new opportunities in cell biology by allowing the specific modulation of gene expression under controlled conditions. Knockdown of genes associated with disease can provide valuable information pertaining to their function and potentially their role in the disease etiology.
Ben, Molloy, Michael, Freeley, Aideen, Long, Ross, McManus   +3 more
openaire   +2 more sources

Gene Knockdown in the Mouse Through RNAi

2010
RNA interference (RNAi)-mediated gene knockdown has developed into a routine method to assess gene function in cultured mammalian cells in a fast and easy manner. For the use of RNAi in mice, short hairpin (sh) RNAs expressed from transgenic vectors are a fast alternative to conventional knockout approaches. We describe our strategy to elicit body-wide,
Kleinhammer, A., Wurst, W., Kühn, R.
openaire   +3 more sources

shRNA-Mediated Gene Knockdown in Skeletal Muscle

2011
RNA interference appears as a promising tool for therapeutic gene silencing to block protein expression. A long-lived silencing is obtained through the in situ expression of shRNA. A safe approach is to use a physical method such as in vivo electropulsation with plate electrodes.
Golzio, Muriel, Escoffre, Jean-Michel, Justin, Teissié   +2 more
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RNA interference as a gene knockdown technique

The International Journal of Biochemistry & Cell Biology, 2010
Not many scientific breakthroughs bring significant advances simultaneously in both basic research and translational applications like the discovery of RNA interference. Along with the elucidation of the RNA interference pathway and the discovery of its participation in crucial biological events, a branch of science has grown to utilize the RNA ...
openaire   +2 more sources