Results 21 to 30 of about 405,164 (304)
Heritable and Lineage-Specific Gene Knockdown in Zebrafish Embryo
PLoS ONE, 2009 Reduced expression of developmentally important genes and tumor suppressors due to haploinsufficiency or epigenetic suppression has been shown to contribute to the pathogenesis of various malignancies. However, methodology that allows spatio-temporally knockdown of gene expression in various model organisms such as zebrafish has not been well ...
Mei Dong +8 more
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Antineovascular Gene Therapy by Ago2 Knockdown
YAKUGAKU ZASSHI, 2008 Small interfering RNA (siRNA), which induces sequence-dependent gene silencing, has been widely studied. We previously developed polycation liposomes (PCL) as carriers of plasmid DNA and succeeded in showing their potent gene expression efficiency.
Kentaro, Hatanaka +3 more
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Conditional gene knockdowns in sea urchins using caged morpholinos
Developmental Biology, 2021 Echinoderms are important experimental models for analyzing embryonic development, but a lack of spatial and temporal control over gene perturbations has hindered developmental studies using these animals. Morpholino antisense oligonucleotides (MOs) have been used successfully by the echinoderm research community for almost two decades, and MOs remain ...
Anirban Bardhan +2 more
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Biomedicines, 2022 Oligonucleotide therapeutics, antisense oligonucleotides (ASOs) and short interfering RNA (siRNA) are short synthetic nucleic acid molecules with a promising potential to treat a wide range of diseases.
Mauro Sousa de Almeida +3 more
doaj +1 more source
USP40 gene knockdown disrupts glomerular permeability in zebrafish [PDF]
American Journal of Physiology-Renal Physiology, 2017 Unbiased transcriptome profiling and functional genomics approaches have identified ubiquitin-specific protease 40 (USP40) as a highly specific glomerular transcript. This gene product remains uncharacterized, and its biological function is completely unknown. Here, we showed that mouse and rat glomeruli exhibit specific expression of the USP40 protein,
Hisashi, Takagi +13 more
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The potential of synthetic small interfering RNA-based antiviral drugs for influenza treatment
Вопросы вирусологии, 2020 Influenza is a worldwide public health problem. Annually, this infection affects up to 15% of the world population; and about half a million people die from this disease every year. Moreover, influenza A and B viruses tend to garner most of the attention,
E. A. Pashkov +4 more
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Frontiers in Cell and Developmental Biology, 2022 Substantial levels of lysozyme in adipose tissue in association to obesity have been recently demonstrated in mice and humans. In addition, experiments in mice suggest that lysozyme might impact on adipose tissue adipogenesis.
Aina Lluch +7 more
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Knockdown of lncRNA H19 suppresses endometriosis in vivo [PDF]
Brazilian Journal of Medical and Biological Research, 2021 The long noncoding RNA (lncRNA) H19 is involved in the pathogenesis of endometriosis by modulating the proliferation and invasion of ectopic endometrial cells in vitro, but related in vivo studies are rare.
Songping Liu +8 more
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Frontiers in Cellular Neuroscience, 2014 Gene knockout by homologous recombination is a popular method to study gene functions in the mouse in vivo. However, its lack of temporal control has limited the interpretation of knockout studies because the complete elimination of a gene product often ...
Fabrice eHeitz +5 more
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Reduced Retinoic Acid Signaling During Gastrulation Induces Developmental Microcephaly
Frontiers in Cell and Developmental Biology, 2022 Retinoic acid (RA) is a central signaling molecule regulating multiple developmental decisions during embryogenesis. Excess RA induces head malformations, primarily by expansion of posterior brain structures at the expense of anterior head regions, i.e.,
Michal Gur +4 more
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