Results 31 to 40 of about 405,164 (304)
Transcriptome analysis reveals the potential biological function of FSCN1 in HeLa cervical cancer cells [PDF]
PeerJ, 2022 Fascin actin-bundling protein 1 (FSCN1), an actin-bundling protein associated with cell migration and invasion, is highly expressed in various tumor tissues. FSCN1 has also been reported to be a marker of increased invasive potential in cervical cancers.
Fengqin Guo +6 more
doaj +2 more sources
siRNA and mRNA-Based Preventive and Therapeutic Strategies for HPV-Induced Cervical Cancer [PDF]
Advanced Pharmaceutical BulletinHuman papillomavirus (HPV), specifically types 16 and 18, is the main cause of cervical cancer and a significant cause of death among women. Specifically, HPV E6 and E7 oncogenes hinder the normal cell cycle regulation, resulting in uncontrolled cell ...
Mansi Khari +4 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Oncolytic adenoviruses are being developed as new anti-cancer agents. Their efficacy can be improved by incorporating RNA interference (RNAi) molecules. RNAi molecules can be expressed in various precursor formats.
Tereza Brachtlova +8 more
doaj +1 more source
Gene Knockdown in Paracoccidioides brasiliensis Using Antisense RNA [PDF]
, 2012 Paracoccidioides brasiliensis is a thermal dimorphic fungus which in the host environment exhibits a multinucleated and multibudding yeast form. The cellular and molecular mechanisms underlying these phenotypes remain to be clarified, mostly due to the absence of efficient classical genetic and molecular techniques.
Menino, João F. +2 more
openaire +3 more sources
Effect of MSTN Mutation on Growth and Carcass Performance in Duroc × Meishan Hybrid Population
Animals, 2020 The Meishan pig is a traditional Chinese native breed, known for its excellent reproduction performance that is widely used in commercial pig production through two-way or three-way crossbreeding systems. However, the lean meat yield of Meishan crossbred
Weijian Li +7 more
doaj +1 more source
Knockdown of Target Genes by siRNA In Vitro
, 2021 RNA interference (RNAi) is a cellular process involved in the silencing of genes, which makes RNAi important for observing and understanding the function of specific gene products. Short interfering RNA (siRNA) pathway is a RNAi pathway, where exogenous double stranded RNA is introduced to the cell and cleaved by an endoribonuclease, Dicer, to form ...
Songhee, Back, James J, Manfredi
openaire +3 more sources
A CRISPR Interference System for Efficient and Rapid Gene Knockdown in
mBio, 2020 CRISPR interference (CRISPRi) is a powerful new tool used in different organisms that provides a fast, specific, and reliable way to knock down gene expression.
Mathilde Guzzo +4 more
doaj +1 more source
RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept
Pharmaceuticals, 2017 Presently, a new era of drug-eluting stents is continuing to improve late adverse effects such as thrombosis after coronary stent implantation in atherosclerotic vessels.
Olivia Koenig +10 more
doaj +1 more source
Poultry Science, 2023 : Receptor interacting protein kinase 2 (RIPK2) is involved in a variety of signaling pathway to produce a series of inflammatory cytokines in response to a diverse of bacterial, viral and protozoal pathogens.
Sun Hong-yan +5 more
doaj +1 more source
siRNA KNOCKDOWN SKP2 GENE IN BREAST CANCER [PDF]
The Egyptian Journal of Biochemistry and Molecular Biology, 2016 The S-phase kinase-associated protein-2 (SKP2) plays a strategic role in ubiquitin-mediated proteolysis, which effects in the development of cells from inactivity to proliferative state. SKP2 is overexpressed in a variety of tumor. In this study, we used small interfering RNAs (siRNAs) to inhibit the SKP2 expression in Breast cancer cells preface ...
openaire +2 more sources