Results 121 to 130 of about 137,996 (276)

A Novel Technique to Specifically Knockdown Maternal Gene Expression in Ciona intestinalis

A Novel Technique to Specifically Knockdown Maternal Gene Expression in Ciona intestinalis
2014 この博士論文は内容の要約のみの公開（または一部非公開 ...
openaire   +1 more source

Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis

Journal of Hepatocellular Carcinoma
Lingling Lu,1,2,* Xiaoling Zhou,2,3,* Jiaolong Zheng,2,3,* Dongliang Li2,3 1Department of Infection Disease, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 2Fuzong Clinical Medical College of Fujian Medical ...
Lu L, Zhou X, Zheng J, Li D
doaj  

Circular RNA hsa_circ_0005519 contributes to acute kidney injury via sponging microRNA-98-5p

BMC Nephrology
Background This study intends to explore the role and molecular mechanism of hsa_circ_0005519 in acute kidney injury (AKI). Methods We conducted reverse transcription-qPCR for human serum to determine levels of hsa_circ_0005519 in AKI patients and ...
Linsen Jiang, Manxin Huang, Jun Ge, Xuefeng Zhang, Ye Liu, Hang Liu, Xiaoming Liu, Lili Jiang   +7 more
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Comprehensive Multi-Omics Analysis Identifies Lactylation-Related Gene RAN as a Novel Prognostic Biomarker and Therapeutic Target in Glioma

Frontiers in Bioscience-Landmark
Background: Gliomas are the most aggressive primary malignancies of the central nervous system (CNS) and exhibit marked heterogeneity that is closely associated with metabolic reprogramming.
Shunda Wang, Fan Tang, Hong Chen, Jingyue Pang, Ying Zhang, Jianjing Yang, Yue Zhang   +6 more
doaj   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

SNX7 mediates inhibition of autophagy in prostate cancer via activation of CFLIP expression

Discover Oncology
Background Prostate cancer (PC) is a major health concern among men worldwide, yet its underlying molecular mechanisms remain incompletely understood.
Liang Qin, Fan Yang, Zhuifeng Guo, Xuwei Lu, Jiawen Wu, Dongzhen Jiang, Ning Yang   +6 more
doaj   +1 more source

Establishing VIGS and CRISPR/Cas9 techniques to verify RsPDS function in radish

Journal of Integrative Agriculture
Virus-induced gene silencing (VIGS) and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) systems are effective technologies for rapid and accurate gene function verification in modern plant biotechnology ...
Jiali Ying, Yan Wang, Liang Xu, Tiaojiao Qin, Kai Xia, Peng Zhang, Yinbo Ma, Keyun Zhang, Lun Wang, Junhui Dong, Lianxue Fan, Yuelin Zhu, Liwang Liu   +12 more
doaj   +1 more source